DegronMD

Uniprot ID: O43852

Source protein: Calumenin

Source gene: CALU

Class: LIG_APCC_ABBAyCdc20_2

Location: 25:31

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8569

ASA_SCORE: 106.6143

COIL: 0.812

CONS_SCORE: 0.4493

DSS_SCORE: 0.555

HELIX: 0.1336

FCONS_SCORE: 1.1456

RIG_SCORE: 0.71

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K32R	TCGA-A2-A04Y	BRCA	TCGA	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K32R	DO2371	BRCA	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.3056
p.A23S	TCGA-B5-A11E	UCEC	TCGA	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A23S	DO41644	UCEC	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S19T	TCGA-CK-5913	COAD	TCGA	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S19T	DO8826	COAD	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P40S	TCGA-FW-A3R5	SKCM	TCGA	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P40S	DO37406	SKCM	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H38P	TCGA-XF-AAMX	BLCA	TCGA	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.1389
p.H38P	DO51939	BLCA	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.1389
p.I40T	DO234234	ESAD	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.D39H	DO219648	KIRP	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.1111
p.F28L	DO23822	LUAD	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.6981
p.P31A	DO221543	PACA	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.7503
p.L18F	DO37406	SKCM	ICGC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V38F	ACH-000692	Head and Neck Cancer	CCLE	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.1389
p.N40I	ACH-000963	Colon/Colorectal Cancer	CCLE	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.0833
p.N40I	CCK-81	large_intestine	COSMIC	KDRVHHE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43852	Calumenin	LIG_APCC_ABBAyCdc20_2	25:31	KDRVHHE	APC,CDC20,FZR1	0.8569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons