DegronMD

Uniprot ID: Q08J23

Source protein: RNA cytosine C

Source gene: NSUN2

Class: LIG_APCC_ABBAyCdc20_2

Location: 257:263

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5476

ASA_SCORE: 57.3714

COIL: 0.3261

CONS_SCORE: 0.4531

DSS_SCORE: 0.0569

HELIX: 0.0197

FCONS_SCORE: 0.8082

RIG_SCORE: 0.9397

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D254Y	TCGA-2F-A9KO	BLCA	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.25
p.G255V	TCGA-75-5126	LUAD	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G255C	TCGA-75-5126	LUAD	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R264Q	TCGA-AA-3984	COAD	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R264Q	TCGA-AP-A051	UCEC	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R264Q	TCGA-AP-A056	UCEC	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R264Q	TCGA-E6-A1LX	UCEC	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R264Q	SIDM00193	Colorectal Carcinoma	GDSC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R264Q	SNU-81	large_intestine	COSMIC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D263Y	TCGA-BS-A0UF	UCEC	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.7325
p.P270S	TCGA-EE-A181	SKCM	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P270L	TCGA-EE-A29E	SKCM	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D252N	TCGA-EV-5901	KIRP	TCGA	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R266Q	DO234364	ESAD	ICGC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.25
p.R266Q	DO35442	PACA	ICGC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.25
p.R266Q	DO42673	UCEC	ICGC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.25
p.T269K	DO229045	LICA	ICGC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S257I	DO25280	LUAD	ICGC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.7341
p.S257N	DO232224	PBCA	ICGC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.7069
p.F261L	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.6981
p.F261L	NCI-H1573	lung	COSMIC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.6981
p.L266S	SIDM01608	Endometrial Carcinoma	GDSC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.25
p.I259T	SIDM01608	Endometrial Carcinoma	GDSC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.5966
p.R264P	ACH-000694	Esophageal Cancer	CCLE	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q259L	ACH-000826	Lung Cancer	CCLE	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.7765
p.Q259L	CAL-12T	lung	COSMIC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.7765
p.N256S	ACH-000993	Endometrial/Uterine Cancer	CCLE	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G271R	ACH-002175	Lung Cancer	CCLE	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G271R	NCI-H740	lung	COSMIC	KEILFYD	LIG_APCC_ABBAyCdc20_2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KEILFYD

Degron related mutations and impact score

Drug responses associated with NSUN2 mutations

All proteins holding degron of KEILFYD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08J23	RNA cytosine C	LIG_APCC_ABBAyCdc20_2	257:263	KEILFYD	APC,CDC20,FZR1	0.5476	More...