DegronMD

Uniprot ID: Q6UB99

Source protein: Ankyrin repeat domain-containing protein 11

Source gene: ANKRD11

Class: LIG_APCC_ABBAyCdc20_2

Location: 791:797

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8545

ASA_SCORE: 121.5429

COIL: 0.4693

CONS_SCORE: 0.4364

DSS_SCORE: 0.3664

HELIX: 0.4964

FCONS_SCORE: 1.1134

RIG_SCORE: 0.7771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K786T	TCGA-FI-A2D5	UCEC	TCGA	KEKIFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K786T	DO41331	UCEC	ICGC	KEKIFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K786N	DO229058	LICA	ICGC	KEKIFKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.F795L	DO232224	PBCA	ICGC	KEKIFKE	LIG_APCC_ABBAyCdc20_2	0.6981
p.I794T	ACH-001030	Bone Cancer	CCLE	KEKIFKE	LIG_APCC_ABBAyCdc20_2	0.7078
p.L802R	ACH-001561	Lung Cancer	CCLE	KEKIFKE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UB99	Ankyrin repeat domain-containing protein 11	LIG_APCC_ABBAyCdc20_2	791:797	KEKIFKE	APC,CDC20,FZR1	0.8545	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons