DegronMD

Uniprot ID: P22888

Source protein: Lutropin-choriogonadotropic hormone receptor

Source gene: LHCGR

Class: LIG_APCC_ABBAyCdc20_2

Location: 205:211

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.989

ASA_SCORE: 76.4857

COIL: 0.7069

CONS_SCORE: 0.4304

DSS_SCORE: 0.39

HELIX: 0.0699

FCONS_SCORE: 0.8391

RIG_SCORE: 0.81

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E203K	TCGA-18-3409	LUSC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E203K	DO26444	LUSC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.N215H	TCGA-34-2609	LUSC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N215H	DO26981	LUSC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N195H	TCGA-44-2656	LUAD	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.N195H	DO26052	LUAD	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.F218Y	TCGA-4Z-AA7W	BLCA	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.F218Y	DO218984	BLCA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A217V	TCGA-A5-A0G2	UCEC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A217V	DO41235	UCEC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T197M	TCGA-CG-5726	STAD	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T197M	DO38483	STAD	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E211D	TCGA-E6-A1LX	UCEC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E211D	DO41020	UCEC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E206D	TCGA-E6-A1LX	UCEC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E206D	DO41020	UCEC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E206K	TCGA-EE-A183	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	TCGA-EE-A20C	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	TCGA-EE-A2GC	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	TCGA-EE-A2GI	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	TCGA-WE-A8ZO	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	DO222775	MELA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	DO222837	MELA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	DO218912	SKCA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	DO37839	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	DO37715	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	DO37410	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	DO47665	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	DO51286	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	SIDM01175	Other Sarcomas	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	SIDM01000	Melanoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	ACH-000304	Skin Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	ACH-002309	Sarcoma	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	WM-115	skin	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.E206K	SW684	soft_tissue	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.591
p.V208I	TCGA-EK-A2PK	CESC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V208I	DO48977	CESC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V208I	DO49096	PACA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V208I	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V208I	SIDM00863	Burkitt's Lymphoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.R219C	TCGA-GF-A3OT	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R219C	DO47288	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A221V	TCGA-QQ-A8VH	SARC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A221V	DO220262	SARC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E211K	TCGA-YD-A9TA	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E211K	DO219503	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.7022
p.L202M	DO229038	LICA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.25
p.S201L	DO222494	MELA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G220V	DO229229	THCA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R219H	SIDM00120	Prostate Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R219H	SIDM01685	B-Lymphoblastic Leukemia	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R219H	ACH-000130	Leukemia	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R219H	ACH-000979	Prostate Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R219H	DU-145	prostate	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H214R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.25
p.H214R	ACH-002059	Leukemia	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.25
p.G196E	SIDM00282	Colorectal Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G196E	ACH-000998	Colon/Colorectal Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G196E	CW-2	large_intestine	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R219S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R219S	ACH-000929	Lung Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R219S	NCI-H2110	lung	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.F218L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.F218L	ACH-000929	Lung Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.F218L	NCI-H2110	lung	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KENVHLE

Degron related mutations and impact score

Drug responses associated with LHCGR mutations

All proteins holding degron of KENVHLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22888	Lutropin-choriogonadotropic hormone receptor	LIG_APCC_ABBAyCdc20_2	205:211	KENVHLE	APC,CDC20,FZR1	0.989	More...