DegronMD - P22888(LHCGR)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E203K	TCGA-18-3409	LUSC	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.3056
p.E203K	TCGA-18-3409	LUSC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.2778
p.E203K	DO26444	LUSC	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.3056
p.E203K	DO26444	LUSC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.2778
p.N215H	TCGA-34-2609	LUSC	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.1389
p.N215H	TCGA-34-2609	LUSC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.2222
p.N215H	DO26981	LUSC	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.1389
p.N215H	DO26981	LUSC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.2222
p.N195H	TCGA-44-2656	LUAD	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0833
p.N195H	TCGA-44-2656	LUAD	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.0556
p.N195H	DO26052	LUAD	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0833
p.N195H	DO26052	LUAD	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.0556
p.F218Y	TCGA-4Z-AA7W	BLCA	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0556
p.F218Y	TCGA-4Z-AA7W	BLCA	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1389
p.F218Y	DO218984	BLCA	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0556
p.F218Y	DO218984	BLCA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1389
p.A217V	TCGA-A5-A0G2	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0833
p.A217V	TCGA-A5-A0G2	UCEC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1667
p.A217V	DO41235	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0833
p.A217V	DO41235	UCEC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1667
p.L204R	TCGA-AX-A0J0	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7316
p.L204R	DO41133	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7316
p.T197M	TCGA-CG-5726	STAD	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.1389
p.T197M	TCGA-CG-5726	STAD	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.T197M	DO38483	STAD	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.1389
p.T197M	DO38483	STAD	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.E211D	TCGA-E6-A1LX	UCEC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.5647
p.E211D	DO41020	UCEC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.5647
p.E206D	TCGA-E6-A1LX	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.6758
p.E206D	TCGA-E6-A1LX	UCEC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.5647
p.E206D	DO41020	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.6758
p.E206D	DO41020	UCEC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.5647
p.E206K	TCGA-EE-A183	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	TCGA-EE-A183	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	TCGA-EE-A20C	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	TCGA-EE-A20C	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	TCGA-EE-A2GC	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	TCGA-EE-A2GC	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	TCGA-EE-A2GI	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	TCGA-EE-A2GI	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	TCGA-WE-A8ZO	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	TCGA-WE-A8ZO	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	DO222775	MELA	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	DO222775	MELA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	DO222837	MELA	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	DO222837	MELA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	DO218912	SKCA	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	DO218912	SKCA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	DO37839	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	DO37839	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	DO37715	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	DO37715	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	DO37410	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	DO37410	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	DO47665	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	DO47665	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	DO51286	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	DO51286	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	SIDM01175	Other Sarcomas	GDSC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	SIDM01175	Other Sarcomas	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	SIDM01000	Melanoma	GDSC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	SIDM01000	Melanoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	ACH-000304	Skin Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	ACH-000304	Skin Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	ACH-002309	Sarcoma	CCLE	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	ACH-002309	Sarcoma	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	WM-115	skin	COSMIC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	WM-115	skin	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.E206K	SW684	soft tissue	COSMIC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.7022
p.E206K	SW684	soft tissue	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.591
p.V208I	TCGA-EK-A2PK	CESC	TCGA	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.5965
p.V208I	TCGA-EK-A2PK	CESC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.5965
p.V208I	DO48977	CESC	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.5965
p.V208I	DO48977	CESC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.5965
p.V208I	DO49096	PACA	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.5965
p.V208I	DO49096	PACA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.5965
p.V208I	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.5965
p.V208I	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.5965
p.V208I	SIDM00863	Burkitt's Lymphoma	GDSC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation altering degron motif	0.5965
p.V208I	SIDM00863	Burkitt's Lymphoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.5965
p.R219C	TCGA-GF-A3OT	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.R219C	DO47288	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.A221V	TCGA-QQ-A8VH	SARC	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.0556
p.A221V	DO220262	SARC	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.0556
p.E211K	TCGA-YD-A9TA	SKCM	TCGA	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.7022
p.E211K	DO219503	SKCM	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation altering degron motif	0.7022
p.L202M	DO229038	LICA	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.2778
p.L202M	DO229038	LICA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.25
p.F194L	DO229041	LICA	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0556
p.F194L	SIDM01588	Endometrial Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0556
p.F194L	ACH-000993	Endometrial/Uterine Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0556
p.S201L	DO222494	MELA	ICGC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.25
p.S201L	DO222494	MELA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.2222
p.G220V	DO229229	THCA	ICGC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.0833
p.R219H	SIDM00120	Prostate Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.R219H	SIDM01685	B-Lymphoblastic Leukemia	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.R219H	ACH-000130	Leukemia	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.R219H	ACH-000979	Prostate Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.R219H	DU-145	prostate	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.H214R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.1667
p.H214R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.25
p.H214R	ACH-002059	Leukemia	CCLE	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.1667
p.H214R	ACH-002059	Leukemia	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.25
p.G196E	SIDM00282	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.1111
p.G196E	SIDM00282	Colorectal Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.0833
p.G196E	ACH-000998	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.1111
p.G196E	ACH-000998	Colon/Colorectal Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.0833
p.G196E	CW-2	large intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.1111
p.G196E	CW-2	large intestine	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.0833
p.R219S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.R219S	ACH-000929	Lung Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.R219S	NCI-H2110	lung	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1111
p.F218L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0556
p.F218L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1389
p.F218L	ACH-000929	Lung Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0556
p.F218L	ACH-000929	Lung Cancer	CCLE	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1389
p.F218L	NCI-H2110	lung	COSMIC	LKENV	DEG_APCC_KENBOX_2	204:208	Mutation rewiring degron network	0.0556
p.F218L	NCI-H2110	lung	COSMIC	KENVHLE	LIG_APCC_ABBAyCdc20_2	205:211	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LHCGR

UniProt ID: P22888

Entrez ID: 3973

Protein name: Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LHCGR in