DegronMD

Uniprot ID: P22888

Source protein: Lutropin-choriogonadotropic hormone receptor

Source gene: LHCGR

Class: DEG_APCC_KENBOX_2

Location: 204:208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9886

ASA_SCORE: 79.6

COIL: 0.745

CONS_SCORE: 0.4287

DSS_SCORE: 0.3926

HELIX: 0.1468

FCONS_SCORE: 0.8382

RIG_SCORE: 0.8111

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E203K	TCGA-18-3409	LUSC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.3056
p.E203K	DO26444	LUSC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.3056
p.N215H	TCGA-34-2609	LUSC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.1389
p.N215H	DO26981	LUSC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.1389
p.N195H	TCGA-44-2656	LUAD	TCGA	LKENV	DEG_APCC_KENBOX_2	0.0833
p.N195H	DO26052	LUAD	ICGC	LKENV	DEG_APCC_KENBOX_2	0.0833
p.F218Y	TCGA-4Z-AA7W	BLCA	TCGA	LKENV	DEG_APCC_KENBOX_2	0.0556
p.F218Y	DO218984	BLCA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.0556
p.A217V	TCGA-A5-A0G2	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.0833
p.A217V	DO41235	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.0833
p.L204R	TCGA-AX-A0J0	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.7316
p.L204R	DO41133	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.7316
p.T197M	TCGA-CG-5726	STAD	TCGA	LKENV	DEG_APCC_KENBOX_2	0.1389
p.T197M	DO38483	STAD	ICGC	LKENV	DEG_APCC_KENBOX_2	0.1389
p.E206D	TCGA-E6-A1LX	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.6758
p.E206D	DO41020	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.6758
p.E206K	TCGA-EE-A183	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	TCGA-EE-A20C	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	TCGA-EE-A2GC	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	TCGA-EE-A2GI	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	TCGA-WE-A8ZO	SKCM	TCGA	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	DO222775	MELA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	DO222837	MELA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	DO218912	SKCA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	DO37839	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	DO37715	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	DO37410	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	DO47665	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	DO51286	SKCM	ICGC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	SIDM01175	Other Sarcomas	GDSC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	SIDM01000	Melanoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	ACH-000304	Skin Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	ACH-002309	Sarcoma	CCLE	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	WM-115	skin	COSMIC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.E206K	SW684	soft_tissue	COSMIC	LKENV	DEG_APCC_KENBOX_2	0.7022
p.V208I	TCGA-EK-A2PK	CESC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.5965
p.V208I	DO48977	CESC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.5965
p.V208I	DO49096	PACA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.5965
p.V208I	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.5965
p.V208I	SIDM00863	Burkitt's Lymphoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.5965
p.L202M	DO229038	LICA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.2778
p.F194L	DO229041	LICA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.0556
p.F194L	SIDM01588	Endometrial Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.0556
p.F194L	ACH-000993	Endometrial/Uterine Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.0556
p.S201L	DO222494	MELA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.25
p.H214R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LKENV	DEG_APCC_KENBOX_2	0.1667
p.H214R	ACH-002059	Leukemia	CCLE	LKENV	DEG_APCC_KENBOX_2	0.1667
p.G196E	SIDM00282	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.1111
p.G196E	ACH-000998	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.1111
p.G196E	CW-2	large_intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	0.1111
p.F218L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.0556
p.F218L	ACH-000929	Lung Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.0556
p.F218L	NCI-H2110	lung	COSMIC	LKENV	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22888	Lutropin-choriogonadotropic hormone receptor	DEG_APCC_KENBOX_2	204:208	LKENV	APC,CDC20,FZR1	0.9886	More...
Q96BD8	Spindle and kinetochore-associated protein 1	DEG_APCC_KENBOX_2	87:91	LKENV	APC,CDC20,FZR1	0.5869	More...
Q9H4I2	Zinc fingers and homeoboxes protein 3	DEG_APCC_KENBOX_2	202:206	LKENV	APC,CDC20,FZR1	0.5352	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKENV

Degron related mutations and impact score

Drug responses associated with LHCGR mutations

All proteins holding degron of LKENV