DegronMD

Uniprot ID: Q96BD8

Source protein: Spindle and kinetochore-associated protein 1

Source gene: SKA1

Class: DEG_APCC_KENBOX_2

Location: 87:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5869

ASA_SCORE: 73.64

COIL: 0.4124

CONS_SCORE: 0.4209

DSS_SCORE: 0.4723

HELIX: 0.5684

FCONS_SCORE: 1.1314

RIG_SCORE: 0.7059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D83Y	TCGA-64-5778	LUAD	TCGA	LKENV	DEG_APCC_KENBOX_2	0.2222
p.D83Y	TCGA-EI-6917	READ	TCGA	LKENV	DEG_APCC_KENBOX_2	0.2222
p.D83Y	DO25837	LUAD	ICGC	LKENV	DEG_APCC_KENBOX_2	0.2222
p.D83Y	DO36881	READ	ICGC	LKENV	DEG_APCC_KENBOX_2	0.2222
p.V91I	DO229010	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.5965
p.V91I	DO229013	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.5965
p.V91I	DO229016	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.5965
p.V91I	DO229003	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.5965
p.V91I	DO229005	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.5965
p.Y81N	DO233297	NACA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.1667
p.I84T	SIDM01045	Endometrial Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.25
p.I84T	ACH-000978	Endometrial/Uterine Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.25
p.I84T	EN	endometrium	COSMIC	LKENV	DEG_APCC_KENBOX_2	0.25
p.H86R	SIDM00721	Small Cell Lung Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.3056
p.D80Y	SIDM01611	Endometrial Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.1389
p.D80Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.1389
p.R100C	SNU-1040	large_intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22888	Lutropin-choriogonadotropic hormone receptor	DEG_APCC_KENBOX_2	204:208	LKENV	APC,CDC20,FZR1	0.9886	More...
Q96BD8	Spindle and kinetochore-associated protein 1	DEG_APCC_KENBOX_2	87:91	LKENV	APC,CDC20,FZR1	0.5869	More...
Q9H4I2	Zinc fingers and homeoboxes protein 3	DEG_APCC_KENBOX_2	202:206	LKENV	APC,CDC20,FZR1	0.5352	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons