DegronMD - Q96BD8(SKA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D83Y	TCGA-64-5778	LUAD	TCGA	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.2222
p.D83Y	TCGA-EI-6917	READ	TCGA	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.2222
p.D83Y	DO25837	LUAD	ICGC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.2222
p.D83Y	DO36881	READ	ICGC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.2222
p.S133R	TCGA-69-7761	LUAD	TCGA	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation rewiring degron network	0.1111
p.S133R	DO23620	LUAD	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation rewiring degron network	0.1111
p.M152I	TCGA-A5-A2K5	UCEC	TCGA	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation rewiring degron network	0.3056
p.F145L	TCGA-D1-A16X	UCEC	TCGA	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation altering degron motif	0.587
p.F145L	DO41799	UCEC	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation altering degron motif	0.587
p.R132I	TCGA-D1-A17Q	UCEC	TCGA	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation rewiring degron network	0.0833
p.R132I	DO41903	UCEC	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation rewiring degron network	0.0833
p.R155H	TCGA-DU-6392	LGG	TCGA	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation rewiring degron network	0.2222
p.D158N	DO223732	CESC	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation blocking phosphorylation signal	0.5833
p.V91I	DO229010	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.5965
p.V91I	DO229013	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.5965
p.V91I	DO229016	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.5965
p.V91I	DO229003	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.5965
p.V91I	DO229005	COCA	ICGC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.5965
p.S150L	DO222653	MELA	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation altering degron motif	0.7667
p.Y81N	DO233297	NACA	ICGC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.1667
p.R145K	DO32019	OV	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation altering degron motif	0.7237
p.S133N	DO218860	SKCA	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation rewiring degron network	0.1111
p.H149Y	DO37881	SKCM	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation altering degron motif	0.7229
p.S142Y	DO37443	SKCM	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation altering degron motif	0.712
p.S142Y	DO42793	UCEC	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation altering degron motif	0.712
p.S139Y	DO42673	UCEC	ICGC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation rewiring degron network	0.2778
p.I84T	SIDM01045	Endometrial Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.25
p.I84T	ACH-000978	Endometrial/Uterine Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.25
p.I84T	EN	endometrium	COSMIC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.25
p.H86R	SIDM00721	Small Cell Lung Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.3056
p.D80Y	SIDM01611	Endometrial Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.1389
p.D80Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.1389
p.E144G	SIDM01619	Endometrial Carcinoma	GDSC	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation altering degron motif	0.7199
p.E144G	ACH-000984	Endometrial/Uterine Cancer	CCLE	TCDEFNGVPSY	DEG_COP1_1	141:151	Mutation altering degron motif	0.7199
p.R100C	SNU-1040	large intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0833

Kaplan plot for SKA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SKA1

UniProt ID: Q96BD8

Entrez ID: 220134

Protein name: Spindle and kinetochore-associated protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SKA1 in