DegronMD

Uniprot ID: Q96BD8

Source protein: Spindle and kinetochore-associated protein 1

Source gene: SKA1

Class: DEG_COP1_1

Location: 141:151

E3 ligase: COP1

DEGRON score: 0.9789

ASA_SCORE: 46.1364

COIL: 0.3891

CONS_SCORE: 0.6485

DSS_SCORE: 0.2978

HELIX: 0.5902

FCONS_SCORE: 1.2155

RIG_SCORE: 0.8065

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S133R	TCGA-69-7761	LUAD	TCGA	TCDEFNGVPSY	DEG_COP1_1	0.1111
p.S133R	DO23620	LUAD	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.1111
p.M152I	TCGA-A5-A2K5	UCEC	TCGA	TCDEFNGVPSY	DEG_COP1_1	0.3056
p.F145L	TCGA-D1-A16X	UCEC	TCGA	TCDEFNGVPSY	DEG_COP1_1	0.587
p.F145L	DO41799	UCEC	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.587
p.R132I	TCGA-D1-A17Q	UCEC	TCGA	TCDEFNGVPSY	DEG_COP1_1	0.0833
p.R132I	DO41903	UCEC	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.0833
p.R155H	TCGA-DU-6392	LGG	TCGA	TCDEFNGVPSY	DEG_COP1_1	0.2222
p.D158N	DO223732	CESC	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.5833
p.S150L	DO222653	MELA	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.7667
p.R145K	DO32019	OV	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.7237
p.S133N	DO218860	SKCA	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.1111
p.H149Y	DO37881	SKCM	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.7229
p.S142Y	DO37443	SKCM	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.712
p.S142Y	DO42793	UCEC	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.712
p.S139Y	DO42673	UCEC	ICGC	TCDEFNGVPSY	DEG_COP1_1	0.2778
p.E144G	SIDM01619	Endometrial Carcinoma	GDSC	TCDEFNGVPSY	DEG_COP1_1	0.7199
p.E144G	ACH-000984	Endometrial/Uterine Cancer	CCLE	TCDEFNGVPSY	DEG_COP1_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BD8	Spindle and kinetochore-associated protein 1	DEG_COP1_1	141:151	TCDEFNGVPSY	COP1	0.9789	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons