DegronMD - Q9H4I2(ZHX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S208G	TCGA-17-Z014	LUAD	TCGA	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.2778
p.E584K	TCGA-49-AAR4	LUAD	TCGA	SPSSKVPEV	DEG_COP1_1	577:585	Mutation altering degron motif	0.7022
p.E584K	DO218920	LUAD	ICGC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation altering degron motif	0.7022
p.E573Q	TCGA-49-AAR4	LUAD	TCGA	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.2222
p.E573Q	DO218920	LUAD	ICGC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.2222
p.K198T	TCGA-A5-A0GP	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation substituting flanking lysine	0.3333
p.K198T	DO41109	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation substituting flanking lysine	0.3333
p.R933H	TCGA-AA-A01R	COAD	TCGA	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7133
p.R933H	TCGA-BR-8080	STAD	TCGA	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7133
p.R933H	TCGA-EY-A1GU	UCEC	TCGA	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7133
p.R933H	DO7934	COAD	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7133
p.R933H	DO38651	STAD	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7133
p.R933H	DO41518	UCEC	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7133
p.R933H	SIDM01770	Gastric Carcinoma	GDSC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7133
p.R933H	ACH-000908	Gastric Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7133
p.I199N	TCGA-AP-A1DV	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.25
p.I199N	DO43186	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.25
p.I199N	SIDM00282	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.25
p.I199N	ACH-000998	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.25
p.I199N	CW-2	large intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.25
p.V206A	TCGA-AX-A06F	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation altering degron motif	0.5825
p.V206A	DO41752	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation altering degron motif	0.5825
p.E573D	TCGA-B5-A3FC	UCEC	TCGA	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.2222
p.E573D	DO41871	UCEC	ICGC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.2222
p.G212D	TCGA-BH-A0HF	BRCA	TCGA	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.1667
p.G212D	DO1749	BRCA	ICGC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.1667
p.S945L	TCGA-BS-A0UV	UCEC	TCGA	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation blocking phosphorylation signal	0.5556
p.S945L	DO222762	COCA	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation blocking phosphorylation signal	0.5556
p.S945L	DO233018	GACA	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation blocking phosphorylation signal	0.5556
p.S945L	DO42793	UCEC	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation blocking phosphorylation signal	0.5556
p.A194V	TCGA-D1-A103	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.1111
p.A194V	DO42312	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.1111
p.P207H	TCGA-DF-A2KN	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.3056
p.P207H	DO223282	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.3056
p.S579L	TCGA-FS-A1ZR	SKCM	TCGA	SPSSKVPEV	DEG_COP1_1	577:585	Mutation altering degron motif	0.7667
p.S579L	DO37651	SKCM	ICGC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation altering degron motif	0.7667
p.S579L	SIDM00315	Glioblastoma	GDSC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation altering degron motif	0.7667
p.S579L	ACH-000570	Brain Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	577:585	Mutation altering degron motif	0.7667
p.S579L	YKG-1	central nervous system	COSMIC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation altering degron motif	0.7667
p.E922D	TCGA-PK-A5HB	ACC	TCGA	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation rewiring degron network	0.1944
p.Y920C	DO225122	BRCA	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation rewiring degron network	0.1389
p.S570C	DO229331	BTCA	ICGC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.1389
p.I199F	DO234239	ESAD	ICGC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.25
p.I199F	SIDM01956	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.25
p.A937T	DO234262	ESAD	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7139
p.S938I	DO48218	ESCA	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation rewiring degron network	0.3056
p.P589S	DO233195	GACA	ICGC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.2222
p.Q623K	DO228952	LICA	ICGC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	608:615	Mutation rewiring degron network	0.1111
p.P932T	DO229027	LICA	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.5919
p.T944I	DO32928	PACA	ICGC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation rewiring degron network	0.1389
p.S929L	SIDM02013	Colorectal Carcinoma	GDSC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.6556
p.P935S	SIDM00084	Glioblastoma	GDSC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.6752
p.P935S	ACH-000376	Brain Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.6752
p.P935S	SF295	central nervous system	COSMIC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.6752
p.E584Q	SIDM00630	Breast Carcinoma	GDSC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation altering degron motif	0.6744
p.E584Q	ACH-000876	Breast Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	577:585	Mutation altering degron motif	0.6744
p.E936K	SIDM00007	Other Solid Cancers	GDSC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7022
p.E936K	ACH-001550	Skin Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7022
p.E936K	MCC13	skin	COSMIC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7022
p.P609L	SIDM00007	Other Solid Cancers	GDSC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	608:615	Mutation altering degron motif	0.6471
p.P609L	ACH-001550	Skin Cancer	CCLE	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	608:615	Mutation altering degron motif	0.6471
p.P609L	MCC13	skin	COSMIC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	608:615	Mutation altering degron motif	0.6471
p.P609S	SIDM00007	Other Solid Cancers	GDSC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	608:615	Mutation altering degron motif	0.5641
p.P609S	ACH-001550	Skin Cancer	CCLE	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	608:615	Mutation altering degron motif	0.5641
p.P609S	MCC13	skin	COSMIC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	608:615	Mutation altering degron motif	0.5641
p.T593I	SIDM00269	Ewing's Sarcoma	GDSC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.1111
p.T593I	ACH-002108	Bone Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.1111
p.T593I	ES7	bone	COSMIC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.1111
p.D569H	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.1111
p.D569H	NCI-H1869	lung	COSMIC	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.1111
p.E931K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7022
p.E931K	ACH-000904	Lung Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7022
p.E931K	ACH-001362	Lung Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7022
p.E931K	NCI-H1770	lung	COSMIC	SESWEPRVPEA	DEG_COP1_1	927:937	Mutation altering degron motif	0.7022
p.L202P	SIDM00537	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation altering degron motif	0.6471
p.L202P	ACH-000982	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation altering degron motif	0.6471
p.L202P	ACH-001345	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation altering degron motif	0.6471
p.L202P	GP5d	large intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation altering degron motif	0.6471
p.P216S	SIDM00217	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.0556
p.P216S	ACH-000999	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.0556
p.P216S	SNU-1040	large intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.0556
p.V571L	ACH-000695	Lung Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.1667
p.F576L	ACH-001063	Ovarian Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	577:585	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZHX3

UniProt ID: Q9H4I2

Entrez ID: 23051

Protein name: Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZHX3 in