DegronMD

Uniprot ID: Q9H4I2

Source protein: Zinc fingers and homeoboxes protein 3

Source gene: ZHX3

Class: DEG_COP1_1

Location: 577:585

E3 ligase: COP1

DEGRON score: 0.8688

ASA_SCORE: 92.4

COIL: 0.9352

CONS_SCORE: 0.4795

DSS_SCORE: 0.4028

HELIX: 0.0276

FCONS_SCORE: 0.9355

RIG_SCORE: 0.684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E584K	TCGA-49-AAR4	LUAD	TCGA	SPSSKVPEV	DEG_COP1_1	0.7022
p.E584K	DO218920	LUAD	ICGC	SPSSKVPEV	DEG_COP1_1	0.7022
p.E573Q	TCGA-49-AAR4	LUAD	TCGA	SPSSKVPEV	DEG_COP1_1	0.2222
p.E573Q	DO218920	LUAD	ICGC	SPSSKVPEV	DEG_COP1_1	0.2222
p.E573D	TCGA-B5-A3FC	UCEC	TCGA	SPSSKVPEV	DEG_COP1_1	0.2222
p.E573D	DO41871	UCEC	ICGC	SPSSKVPEV	DEG_COP1_1	0.2222
p.S579L	TCGA-FS-A1ZR	SKCM	TCGA	SPSSKVPEV	DEG_COP1_1	0.7667
p.S579L	DO37651	SKCM	ICGC	SPSSKVPEV	DEG_COP1_1	0.7667
p.S579L	SIDM00315	Glioblastoma	GDSC	SPSSKVPEV	DEG_COP1_1	0.7667
p.S579L	ACH-000570	Brain Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	0.7667
p.S579L	YKG-1	central_nervous_system	COSMIC	SPSSKVPEV	DEG_COP1_1	0.7667
p.S570C	DO229331	BTCA	ICGC	SPSSKVPEV	DEG_COP1_1	0.1389
p.P589S	DO233195	GACA	ICGC	SPSSKVPEV	DEG_COP1_1	0.2222
p.E584Q	SIDM00630	Breast Carcinoma	GDSC	SPSSKVPEV	DEG_COP1_1	0.6744
p.E584Q	ACH-000876	Breast Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	0.6744
p.T593I	SIDM00269	Ewing's Sarcoma	GDSC	SPSSKVPEV	DEG_COP1_1	0.1111
p.T593I	ACH-002108	Bone Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	0.1111
p.T593I	ES7	bone	COSMIC	SPSSKVPEV	DEG_COP1_1	0.1111
p.D569H	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	SPSSKVPEV	DEG_COP1_1	0.1111
p.D569H	NCI-H1869	lung	COSMIC	SPSSKVPEV	DEG_COP1_1	0.1111
p.V571L	ACH-000695	Lung Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	0.1667
p.F576L	ACH-001063	Ovarian Cancer	CCLE	SPSSKVPEV	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4I2	Zinc fingers and homeoboxes protein 3	DEG_COP1_1	577:585	SPSSKVPEV	COP1	0.8688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons