DegronMD

Uniprot ID: Q9H4I2

Source protein: Zinc fingers and homeoboxes protein 3

Source gene: ZHX3

Class: DEG_COP1_1

Location: 927:937

E3 ligase: COP1

DEGRON score: 0.9481

ASA_SCORE: 92.8

COIL: 0.8892

CONS_SCORE: 0.4688

DSS_SCORE: 0.7115

HELIX: 0.0654

FCONS_SCORE: 1.0896

RIG_SCORE: 0.6499

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R933H	TCGA-AA-A01R	COAD	TCGA	SESWEPRVPEA	DEG_COP1_1	0.7133
p.R933H	TCGA-BR-8080	STAD	TCGA	SESWEPRVPEA	DEG_COP1_1	0.7133
p.R933H	TCGA-EY-A1GU	UCEC	TCGA	SESWEPRVPEA	DEG_COP1_1	0.7133
p.R933H	DO7934	COAD	ICGC	SESWEPRVPEA	DEG_COP1_1	0.7133
p.R933H	DO38651	STAD	ICGC	SESWEPRVPEA	DEG_COP1_1	0.7133
p.R933H	DO41518	UCEC	ICGC	SESWEPRVPEA	DEG_COP1_1	0.7133
p.R933H	SIDM01770	Gastric Carcinoma	GDSC	SESWEPRVPEA	DEG_COP1_1	0.7133
p.R933H	ACH-000908	Gastric Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	0.7133
p.S945L	TCGA-BS-A0UV	UCEC	TCGA	SESWEPRVPEA	DEG_COP1_1	0.5556
p.S945L	DO222762	COCA	ICGC	SESWEPRVPEA	DEG_COP1_1	0.5556
p.S945L	DO233018	GACA	ICGC	SESWEPRVPEA	DEG_COP1_1	0.5556
p.S945L	DO42793	UCEC	ICGC	SESWEPRVPEA	DEG_COP1_1	0.5556
p.E922D	TCGA-PK-A5HB	ACC	TCGA	SESWEPRVPEA	DEG_COP1_1	0.1944
p.Y920C	DO225122	BRCA	ICGC	SESWEPRVPEA	DEG_COP1_1	0.1389
p.A937T	DO234262	ESAD	ICGC	SESWEPRVPEA	DEG_COP1_1	0.7139
p.S938I	DO48218	ESCA	ICGC	SESWEPRVPEA	DEG_COP1_1	0.3056
p.P932T	DO229027	LICA	ICGC	SESWEPRVPEA	DEG_COP1_1	0.5919
p.T944I	DO32928	PACA	ICGC	SESWEPRVPEA	DEG_COP1_1	0.1389
p.S929L	SIDM02013	Colorectal Carcinoma	GDSC	SESWEPRVPEA	DEG_COP1_1	0.6556
p.P935S	SIDM00084	Glioblastoma	GDSC	SESWEPRVPEA	DEG_COP1_1	0.6752
p.P935S	ACH-000376	Brain Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	0.6752
p.P935S	SF295	central_nervous_system	COSMIC	SESWEPRVPEA	DEG_COP1_1	0.6752
p.E936K	SIDM00007	Other Solid Cancers	GDSC	SESWEPRVPEA	DEG_COP1_1	0.7022
p.E936K	ACH-001550	Skin Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	0.7022
p.E936K	MCC13	skin	COSMIC	SESWEPRVPEA	DEG_COP1_1	0.7022
p.E931K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	SESWEPRVPEA	DEG_COP1_1	0.7022
p.E931K	ACH-000904	Lung Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	0.7022
p.E931K	ACH-001362	Lung Cancer	CCLE	SESWEPRVPEA	DEG_COP1_1	0.7022
p.E931K	NCI-H1770	lung	COSMIC	SESWEPRVPEA	DEG_COP1_1	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SESWEPRVPEA

Degron related mutations and impact score

Drug responses associated with ZHX3 mutations

All proteins holding degron of SESWEPRVPEA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4I2	Zinc fingers and homeoboxes protein 3	DEG_COP1_1	927:937	SESWEPRVPEA	COP1	0.9481	More...