DegronMD

Uniprot ID: Q9H4I2

Source protein: Zinc fingers and homeoboxes protein 3

Source gene: ZHX3

Class: DEG_SCF_SKP2-CKS1_1

Location: 608:615

E3 ligase: SKP2,CSK1

DEGRON score: 0.9809

ASA_SCORE: 89.1625

COIL: 0.9008

CONS_SCORE: 0.7658

DSS_SCORE: 0.6263

HELIX: 0.061

FCONS_SCORE: 1.128

RIG_SCORE: 0.714

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q623K	DO228952	LICA	ICGC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P609L	SIDM00007	Other Solid Cancers	GDSC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	0.6471
p.P609L	ACH-001550	Skin Cancer	CCLE	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	0.6471
p.P609L	MCC13	skin	COSMIC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	0.6471
p.P609S	SIDM00007	Other Solid Cancers	GDSC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	0.5641
p.P609S	ACH-001550	Skin Cancer	CCLE	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	0.5641
p.P609S	MCC13	skin	COSMIC	TPDFTPTK	DEG_SCF_SKP2-CKS1_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4I2	Zinc fingers and homeoboxes protein 3	DEG_SCF_SKP2-CKS1_1	608:615	TPDFTPTK	SKP2,CSK1	0.9809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons