DegronMD

Uniprot ID: Q9H4I2

Source protein: Zinc fingers and homeoboxes protein 3

Source gene: ZHX3

Class: DEG_APCC_KENBOX_2

Location: 202:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5352

ASA_SCORE: 111.8

COIL: 0.776

CONS_SCORE: 0.4512

DSS_SCORE: 0.5058

HELIX: 0.1772

FCONS_SCORE: 0.897

RIG_SCORE: 0.7225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S208G	TCGA-17-Z014	LUAD	TCGA	LKENV	DEG_APCC_KENBOX_2	0.2778
p.K198T	TCGA-A5-A0GP	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.3333
p.K198T	DO41109	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.3333
p.I199N	TCGA-AP-A1DV	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.25
p.I199N	DO43186	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.25
p.I199N	SIDM00282	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.25
p.I199N	ACH-000998	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.25
p.I199N	CW-2	large_intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	0.25
p.V206A	TCGA-AX-A06F	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.5825
p.V206A	DO41752	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.5825
p.G212D	TCGA-BH-A0HF	BRCA	TCGA	LKENV	DEG_APCC_KENBOX_2	0.1667
p.G212D	DO1749	BRCA	ICGC	LKENV	DEG_APCC_KENBOX_2	0.1667
p.A194V	TCGA-D1-A103	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.1111
p.A194V	DO42312	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.1111
p.P207H	TCGA-DF-A2KN	UCEC	TCGA	LKENV	DEG_APCC_KENBOX_2	0.3056
p.P207H	DO223282	UCEC	ICGC	LKENV	DEG_APCC_KENBOX_2	0.3056
p.I199F	DO234239	ESAD	ICGC	LKENV	DEG_APCC_KENBOX_2	0.25
p.I199F	SIDM01956	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.25
p.L202P	SIDM00537	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.6471
p.L202P	ACH-000982	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.6471
p.L202P	ACH-001345	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.6471
p.L202P	GP5d	large_intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	0.6471
p.P216S	SIDM00217	Colorectal Carcinoma	GDSC	LKENV	DEG_APCC_KENBOX_2	0.0556
p.P216S	ACH-000999	Colon/Colorectal Cancer	CCLE	LKENV	DEG_APCC_KENBOX_2	0.0556
p.P216S	SNU-1040	large_intestine	COSMIC	LKENV	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22888	Lutropin-choriogonadotropic hormone receptor	DEG_APCC_KENBOX_2	204:208	LKENV	APC,CDC20,FZR1	0.9886	More...
Q96BD8	Spindle and kinetochore-associated protein 1	DEG_APCC_KENBOX_2	87:91	LKENV	APC,CDC20,FZR1	0.5869	More...
Q9H4I2	Zinc fingers and homeoboxes protein 3	DEG_APCC_KENBOX_2	202:206	LKENV	APC,CDC20,FZR1	0.5352	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKENV

Degron related mutations and impact score

Drug responses associated with ZHX3 mutations

All proteins holding degron of LKENV