DegronMD

Uniprot ID: Q9H7L9

Source protein: Sin3 histone deacetylase corepressor complex component SDS3

Source gene: SUDS3

Class: LIG_APCC_ABBAyCdc20_2

Location: 69:75

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9814

ASA_SCORE: 80.1429

COIL: 0.0257

CONS_SCORE: 0.7238

DSS_SCORE: 0.4701

HELIX: 0.9736

FCONS_SCORE: 1.3026

RIG_SCORE: 0.7984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E67G	TCGA-DF-A2KU	UCEC	TCGA	KEQMYQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E67G	DO223286	UCEC	ICGC	KEQMYQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K69N	TCGA-ER-A19P	SKCM	TCGA	KEQMYQD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K69N	DO47623	SKCM	ICGC	KEQMYQD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K59E	DO230326	COCA	ICGC	KEQMYQD	LIG_APCC_ABBAyCdc20_2	0.1667
p.M68T	DO233757	GACA	ICGC	KEQMYQD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7L9	Sin3 histone deacetylase corepressor complex component SDS3	LIG_APCC_ABBAyCdc20_2	69:75	KEQMYQD	APC,CDC20,FZR1	0.9814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons