DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KEQMYQD
Uniprot ID:
Q9H7L9
Source protein:
Sin3 histone deacetylase corepressor complex component SDS3
Source gene:
SUDS3
Class:
LIG_APCC_ABBAyCdc20_2
Location:
69:75
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9814
ASA_SCORE:
80.1429
COIL:
0.0257
CONS_SCORE:
0.7238
DSS_SCORE:
0.4701
HELIX:
0.9736
FCONS_SCORE:
1.3026
RIG_SCORE:
0.7984
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K69N
TCGA-ER-A19P
SKCM
TCGA
KEQMYQD
LIG_APCC_ABBAyCdc20_2
0.6918
p.K69N
DO47623
SKCM
ICGC
KEQMYQD
LIG_APCC_ABBAyCdc20_2
0.6918
p.M68T
DO233757
GACA
ICGC
KEQMYQD
LIG_APCC_ABBAyCdc20_2
0.3056
p.E67G
TCGA-DF-A2KU
UCEC
TCGA
KEQMYQD
LIG_APCC_ABBAyCdc20_2
0.2778
p.E67G
DO223286
UCEC
ICGC
KEQMYQD
LIG_APCC_ABBAyCdc20_2
0.2778
p.K59E
DO230326
COCA
ICGC
KEQMYQD
LIG_APCC_ABBAyCdc20_2
0.1667
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Drug responses associated with SUDS3 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of KEQMYQD
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H7L9
Sin3 histone deacetylase corepressor complex component SDS3
LIG_APCC_ABBAyCdc20_2
69:75
KEQMYQD
APC,CDC20,FZR1
0.9814
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