DegronMD - Q9H7L9(SUDS3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E67G	TCGA-DF-A2KU	UCEC	TCGA	KEQMYQD	LIG_APCC_ABBAyCdc20_2	69:75	Mutation rewiring degron network	0.2778
p.E67G	DO223286	UCEC	ICGC	KEQMYQD	LIG_APCC_ABBAyCdc20_2	69:75	Mutation rewiring degron network	0.2778
p.K69N	TCGA-ER-A19P	SKCM	TCGA	KEQMYQD	LIG_APCC_ABBAyCdc20_2	69:75	Mutation altering degron motif	0.6918
p.K69N	DO47623	SKCM	ICGC	KEQMYQD	LIG_APCC_ABBAyCdc20_2	69:75	Mutation altering degron motif	0.6918
p.E254K	TCGA-F7-A624	HNSC	TCGA	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1667
p.E254K	DO44440	HNSC	ICGC	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1667
p.S248F	TCGA-GM-A2D9	BRCA	TCGA	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.9093
p.S248F	DO4810	BRCA	ICGC	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.9093
p.K59E	DO230326	COCA	ICGC	KEQMYQD	LIG_APCC_ABBAyCdc20_2	69:75	Mutation substituting flanking lysine	0.1667
p.R256L	DO233281	GACA	ICGC	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1111
p.M68T	DO233757	GACA	ICGC	KEQMYQD	LIG_APCC_ABBAyCdc20_2	69:75	Mutation rewiring degron network	0.3056
p.P232A	DO50929	LICA	ICGC	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.0833
p.S237C	DO27869	ORCA	ICGC	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation blocking phosphorylation signal	0.6667
p.P242T	DO46333	OV	ICGC	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.5919
p.A246T	SIDM01664	Prostate Carcinoma	GDSC	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.6028
p.A246T	ACH-000952	Prostate Cancer	CCLE	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.6028
p.A246V	ACH-000976	Bile Duct Cancer	CCLE	LPATPAES	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.5825

Kaplan plot for SUDS3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUDS3

UniProt ID: Q9H7L9

Entrez ID: 64426

Protein name: Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUDS3 in