DegronMD

Uniprot ID: Q9H7L9

Source protein: Sin3 histone deacetylase corepressor complex component SDS3

Source gene: SUDS3

Class: DEG_SCF_FBW7_1

Location: 241:248

E3 ligase: FBXW7

DEGRON score: 0.896

ASA_SCORE: 66.3375

COIL: 0.8615

CONS_SCORE: 0.4939

DSS_SCORE: 0.7078

HELIX: 0.0598

FCONS_SCORE: 0.8593

RIG_SCORE: 0.6032

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E254K	TCGA-F7-A624	HNSC	TCGA	LPATPAES	DEG_SCF_FBW7_1	0.1667
p.E254K	DO44440	HNSC	ICGC	LPATPAES	DEG_SCF_FBW7_1	0.1667
p.S248F	TCGA-GM-A2D9	BRCA	TCGA	LPATPAES	DEG_SCF_FBW7_1	0.9093
p.S248F	DO4810	BRCA	ICGC	LPATPAES	DEG_SCF_FBW7_1	0.9093
p.R256L	DO233281	GACA	ICGC	LPATPAES	DEG_SCF_FBW7_1	0.1111
p.P232A	DO50929	LICA	ICGC	LPATPAES	DEG_SCF_FBW7_1	0.0833
p.S237C	DO27869	ORCA	ICGC	LPATPAES	DEG_SCF_FBW7_1	0.6667
p.P242T	DO46333	OV	ICGC	LPATPAES	DEG_SCF_FBW7_1	0.5919
p.A246T	SIDM01664	Prostate Carcinoma	GDSC	LPATPAES	DEG_SCF_FBW7_1	0.6028
p.A246T	ACH-000952	Prostate Cancer	CCLE	LPATPAES	DEG_SCF_FBW7_1	0.6028
p.A246V	ACH-000976	Bile Duct Cancer	CCLE	LPATPAES	DEG_SCF_FBW7_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7L9	Sin3 histone deacetylase corepressor complex component SDS3	DEG_SCF_FBW7_1	241:248	LPATPAES	FBXW7	0.896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons