DegronMD

Uniprot ID: Q12879

Source protein: Glutamate receptor ionotropic, NMDA 2A

Source gene: GRIN2A

Class: LIG_APCC_ABBAyCdc20_2

Location: 952:958

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9992

ASA_SCORE: 80.7286

COIL: 0.7353

CONS_SCORE: 0.3784

DSS_SCORE: 0.3847

HELIX: 0.1827

FCONS_SCORE: 1.2813

RIG_SCORE: 0.7533

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E962K	TCGA-18-3409	LUSC	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	TCGA-A5-A2K5	UCEC	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	TCGA-BF-AAP4	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	TCGA-CA-6718	COAD	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	TCGA-EE-A2MS	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	TCGA-YD-A9TA	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	DO7801	COAD	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	DO26444	LUSC	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	DO37567	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	DO219468	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	DO219503	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	DO41379	UCEC	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	SIDM00214	Colorectal Carcinoma	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	ACH-000955	Colon/Colorectal Cancer	CCLE	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E962K	SNU-407	large_intestine	COSMIC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A968P	TCGA-50-6590	LUAD	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A968P	DO24692	LUAD	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M960I	TCGA-BH-A2L8	BRCA	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.M960I	DO44242	BRCA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S954N	TCGA-EI-6917	READ	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.5958
p.S954N	DO36881	READ	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.5958
p.F966C	TCGA-EO-A22R	UCEC	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.F966C	DO42713	UCEC	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E953Q	TCGA-FW-A3R5	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.5633
p.E953Q	DO37406	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.5633
p.N946S	TCGA-WE-AAA0	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.N946S	DO51294	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G951V	DO233855	GACA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G951V	SIDM01047	Chronic Myelogenous Leukemia	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G951V	SIDM01001	Breast Carcinoma	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L963I	DO228976	LICA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N959K	DO229042	LICA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G951E	DO220906	MELA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G951E	SIDM00975	Melanoma	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G951E	WM278	skin	COSMIC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q950E	DO50657	ORCA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A968V	DO218874	SKCA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E953K	DO218840	SKCA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.591
p.N946T	SIDM01118	Small Cell Lung Carcinoma	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.N946T	ACH-002175	Lung Cancer	CCLE	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.N946T	NCI-H740	lung	COSMIC	KESIFGD	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KESIFGD

Degron related mutations and impact score

Drug responses associated with GRIN2A mutations

All proteins holding degron of KESIFGD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12879	Glutamate receptor ionotropic, NMDA 2A	LIG_APCC_ABBAyCdc20_2	952:958	KESIFGD	APC,CDC20,FZR1	0.9992	More...