DegronMD - Q12879(GRIN2A)

GRIN2A

UniProt ID: Q12879

Entrez ID: 2903

Protein name: Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)

External links: UniprotKB HGNC RefSeq COSMIC

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E962K	TCGA-18-3409	LUSC	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	TCGA-A5-A2K5	UCEC	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	TCGA-BF-AAP4	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	TCGA-CA-6718	COAD	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	TCGA-EE-A2MS	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	TCGA-YD-A9TA	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	DO7801	COAD	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	DO26444	LUSC	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	DO37567	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	DO219468	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	DO219503	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	DO41379	UCEC	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	SIDM00214	Colorectal Carcinoma	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	ACH-000955	Colon/Colorectal Cancer	CCLE	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.E962K	SNU-407	large intestine	COSMIC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2222
p.A968P	TCGA-50-6590	LUAD	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.0556
p.A968P	DO24692	LUAD	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.0556
p.R1159C	TCGA-55-8203	LUAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159C	TCGA-D1-A16Y	UCEC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159C	TCGA-EO-A22R	UCEC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159C	DO218928	LUAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159C	DO230950	LUSC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159C	DO224638	LUSC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159C	DO41524	UCEC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159C	DO42713	UCEC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.T1164K	TCGA-55-8205	LUAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation blocking phosphorylation signal	0.6389
p.T1164K	DO48884	LUAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation blocking phosphorylation signal	0.6389
p.G1161A	TCGA-56-7221	LUSC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.1111
p.G1161A	DO26689	LUSC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.1111
p.R1159H	TCGA-77-6842	LUSC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159H	TCGA-AA-A02R	COAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159H	TCGA-BR-8286	STAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159H	TCGA-VQ-A91D	STAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159H	DO27413	LUSC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159H	DO38400	STAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.R1159H	DO51783	STAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.0556
p.T1164M	TCGA-AA-3530	COAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation blocking phosphorylation signal	0.6389
p.T1164M	TCGA-DM-A1HB	COAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation blocking phosphorylation signal	0.6389
p.T1164M	DO8970	COAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation blocking phosphorylation signal	0.6389
p.M960I	TCGA-BH-A2L8	BRCA	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2778
p.M960I	DO44242	BRCA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2778
p.R1169Q	TCGA-D1-A16J	UCEC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.7329
p.R1169Q	DO43033	UCEC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.7329
p.E1175K	TCGA-D8-A1JC	BRCA	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.7022
p.E1175K	TCGA-EB-A5UM	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.7022
p.E1175K	TCGA-EE-A3AA	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.7022
p.E1175K	DO6056	BRCA	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.7022
p.E1175K	DO222632	MELA	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.7022
p.E1175K	DO37571	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.7022
p.E1175K	DO47282	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.7022
p.P1171S	TCGA-EE-A2GS	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.5641
p.P1171S	DO37465	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.5641
p.S954N	TCGA-EI-6917	READ	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation altering degron motif	0.5958
p.S954N	DO36881	READ	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation altering degron motif	0.5958
p.F966C	TCGA-EO-A22R	UCEC	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.1111
p.F966C	DO42713	UCEC	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.1111
p.D1162N	TCGA-FS-A1ZA	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.1389
p.D1162N	DO37551	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.1389
p.E953Q	TCGA-FW-A3R5	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation altering degron motif	0.5633
p.E953Q	DO37406	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation altering degron motif	0.5633
p.G1161R	TCGA-W3-A828	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.1111
p.G1161R	DO51273	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.1111
p.N946S	TCGA-WE-AAA0	SKCM	TCGA	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.1667
p.N946S	DO51294	SKCM	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.1667
p.R1169W	TCGA-ZB-A96M	THYM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.8634
p.R1169W	DO228532	MALY	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.8634
p.R1169W	DO33091	PACA	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.8634
p.R1169W	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.8634
p.R1169W	HCC-366	lung	COSMIC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.8634
p.D1182N	DO50412	ESAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.1389
p.G951V	DO233855	GACA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.3056
p.G951V	SIDM01047	Chronic Myelogenous Leukemia	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.3056
p.G951V	SIDM01001	Breast Carcinoma	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.3056
p.L963I	DO228976	LICA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.1944
p.N959K	DO229042	LICA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.3056
p.G951E	DO220906	MELA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.3056
p.G951E	SIDM00975	Melanoma	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.3056
p.G951E	WM278	skin	COSMIC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.3056
p.Q950E	DO50657	ORCA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.2778
p.D1162V	DO227553	ORCA	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.1389
p.A968V	DO218874	SKCA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.0556
p.E953K	DO218840	SKCA	ICGC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation altering degron motif	0.591
p.M1167I	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.2778
p.M1167I	ACH-000823	Esophageal Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.2778
p.M1167I	KYSE-140	oesophagus	COSMIC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.2778
p.N946T	SIDM01118	Small Cell Lung Carcinoma	GDSC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.1667
p.N946T	ACH-002175	Lung Cancer	CCLE	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.1667
p.N946T	NCI-H740	lung	COSMIC	KESIFGD	LIG_APCC_ABBAyCdc20_2	952:958	Mutation rewiring degron network	0.1667
p.E1175D	SIDM00814	Other Solid Cancers	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.5647
p.E1175D	ACH-001401	Adrenal Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.5647
p.E1175D	SW13	adrenal gland	COSMIC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation altering degron motif	0.5647
p.N1168S	SIDM00975	Melanoma	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.3056
p.N1168S	ACH-002206	Skin Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.3056
p.N1168S	WM278	skin	COSMIC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.3056
p.L1178F	SIDM01608	Endometrial Carcinoma	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.25
p.L1178F	ACH-000990	Endometrial/Uterine Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation rewiring degron network	0.25
p.Y1184C	ACH-001091	Colon/Colorectal Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	1169:1175	Mutation blocking phosphorylation signal	0.5278

Kaplan plot for GRIN2A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc