DegronMD

Uniprot ID: Q12879

Source protein: Glutamate receptor ionotropic, NMDA 2A

Source gene: GRIN2A

Class: LIG_APCC_ABBAyCdc20_2

Location: 1169:1175

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9983

ASA_SCORE: 79.6143

COIL: 0.8103

CONS_SCORE: 0.2943

DSS_SCORE: 0.6628

HELIX: 0.1169

FCONS_SCORE: 1.0433

RIG_SCORE: 0.6641

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1159C	TCGA-55-8203	LUAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159C	TCGA-D1-A16Y	UCEC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159C	TCGA-EO-A22R	UCEC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159C	DO218928	LUAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159C	DO230950	LUSC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159C	DO224638	LUSC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159C	DO41524	UCEC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159C	DO42713	UCEC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T1164K	TCGA-55-8205	LUAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.6389
p.T1164K	DO48884	LUAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.6389
p.G1161A	TCGA-56-7221	LUSC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G1161A	DO26689	LUSC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1159H	TCGA-77-6842	LUSC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159H	TCGA-AA-A02R	COAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159H	TCGA-BR-8286	STAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159H	TCGA-VQ-A91D	STAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159H	DO27413	LUSC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159H	DO38400	STAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R1159H	DO51783	STAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T1164M	TCGA-AA-3530	COAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.6389
p.T1164M	TCGA-DM-A1HB	COAD	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.6389
p.T1164M	DO8970	COAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.6389
p.R1169Q	TCGA-D1-A16J	UCEC	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R1169Q	DO43033	UCEC	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.7329
p.E1175K	TCGA-D8-A1JC	BRCA	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1175K	TCGA-EB-A5UM	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1175K	TCGA-EE-A3AA	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1175K	DO6056	BRCA	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1175K	DO222632	MELA	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1175K	DO37571	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E1175K	DO47282	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.P1171S	TCGA-EE-A2GS	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.5641
p.P1171S	DO37465	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.5641
p.D1162N	TCGA-FS-A1ZA	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D1162N	DO37551	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1161R	TCGA-W3-A828	SKCM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G1161R	DO51273	SKCM	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1169W	TCGA-ZB-A96M	THYM	TCGA	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R1169W	DO228532	MALY	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R1169W	DO33091	PACA	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R1169W	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R1169W	HCC-366	lung	COSMIC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.8634
p.D1182N	DO50412	ESAD	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D1162V	DO227553	ORCA	ICGC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.M1167I	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.M1167I	ACH-000823	Esophageal Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.M1167I	KYSE-140	oesophagus	COSMIC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E1175D	SIDM00814	Other Solid Cancers	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E1175D	ACH-001401	Adrenal Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E1175D	SW13	adrenal_gland	COSMIC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.5647
p.N1168S	SIDM00975	Melanoma	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.N1168S	ACH-002206	Skin Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.N1168S	WM278	skin	COSMIC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.L1178F	SIDM01608	Endometrial Carcinoma	GDSC	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.25
p.L1178F	ACH-000990	Endometrial/Uterine Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.25
p.Y1184C	ACH-001091	Colon/Colorectal Cancer	CCLE	RNPLHNE	LIG_APCC_ABBAyCdc20_2	0.5278

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RNPLHNE

Degron related mutations and impact score

Drug responses associated with GRIN2A mutations

All proteins holding degron of RNPLHNE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12879	Glutamate receptor ionotropic, NMDA 2A	LIG_APCC_ABBAyCdc20_2	1169:1175	RNPLHNE	APC,CDC20,FZR1	0.9983	More...