DegronMD

Uniprot ID: Q9NRH1

Source protein: Protein YAE1 homolog

Source gene: YAE1

Class: LIG_APCC_ABBAyCdc20_2

Location: 16:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9968

ASA_SCORE: 73.8857

COIL: 0.6986

CONS_SCORE: 0.511

DSS_SCORE: 0.5615

HELIX: 0.2423

FCONS_SCORE: 1.2404

RIG_SCORE: 0.7362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q31R	SIDM01314	Colorectal Carcinoma	GDSC	KGDVFDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A30V	SIDM00945	Colorectal Carcinoma	GDSC	KGDVFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A30V	CL-34	large_intestine	COSMIC	KGDVFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P13S	SIDM00807	Bladder Carcinoma	GDSC	KGDVFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.D21E	SIDM00213	Thyroid Gland Carcinoma	GDSC	KGDVFDE	LIG_APCC_ABBAyCdc20_2	0.5647
p.D21E	SIDM00228	Thyroid Gland Carcinoma	GDSC	KGDVFDE	LIG_APCC_ABBAyCdc20_2	0.5647
p.D21E	FTC-133	thyroid	COSMIC	KGDVFDE	LIG_APCC_ABBAyCdc20_2	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRH1	Protein YAE1 homolog	LIG_APCC_ABBAyCdc20_2	16:22	KGDVFDE	APC,CDC20,FZR1	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons