DegronMD

Uniprot ID: Q15021

Source protein: Condensin complex subunit 1

Source gene: NCAPD2

Class: LIG_APCC_ABBAyCdc20_2

Location: 855:861

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5025

ASA_SCORE: 47.3

COIL: 0.8704

CONS_SCORE: 0.2866

DSS_SCORE: 0.152

HELIX: 0.0916

FCONS_SCORE: 0.6432

RIG_SCORE: 0.7887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P866L	TCGA-2W-A8YY	CESC	TCGA	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P866L	DO223732	CESC	ICGC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E847Q	TCGA-86-8056	LUAD	TCGA	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E847Q	DO24950	LUAD	ICGC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P866Q	DO228943	LICA	ICGC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E869K	DO220876	MELA	ICGC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R850Q	SIDM00537	Colorectal Carcinoma	GDSC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R850Q	GP5d	large_intestine	COSMIC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D861Y	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.7325
p.D861Y	ACH-001127	Leukemia	CCLE	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.7325
p.D861Y	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15021	Condensin complex subunit 1	LIG_APCC_ABBAyCdc20_2	855:861	KGFVHPD	APC,CDC20,FZR1	0.5025	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons