DegronMD - Q15021(NCAPD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P866L	TCGA-2W-A8YY	CESC	TCGA	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation rewiring degron network	0.1944
p.P866L	DO223732	CESC	ICGC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation rewiring degron network	0.1944
p.E847Q	TCGA-86-8056	LUAD	TCGA	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation rewiring degron network	0.1111
p.E847Q	DO24950	LUAD	ICGC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation rewiring degron network	0.1111
p.T1384I	TCGA-91-6829	LUAD	TCGA	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation altering degron motif	0.7078
p.T1384I	DO23564	LUAD	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation altering degron motif	0.7078
p.A1394V	TCGA-L3-A4E7	LUSC	TCGA	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation rewiring degron network	0.1389
p.A1394V	DO45458	LUSC	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation rewiring degron network	0.1389
p.R1397C	DO230336	COCA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation rewiring degron network	0.0556
p.E1383K	DO222864	COCA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation altering degron motif	0.591
p.E1383K	DO233823	GACA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation altering degron motif	0.591
p.E1383K	SIDM01187	Breast Carcinoma	GDSC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation altering degron motif	0.591
p.E1383K	SIDM00667	Other Sarcomas	GDSC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation altering degron motif	0.591
p.P866Q	DO228943	LICA	ICGC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation rewiring degron network	0.1944
p.K1386R	DO23428	LINC	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation altering degron motif	0.6126
p.E869K	DO220876	MELA	ICGC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation rewiring degron network	0.1111
p.P1385S	DO220899	MELA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation altering degron motif	0.6752
p.P1390S	DO220908	MELA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation rewiring degron network	0.25
p.S1370C	SIDM00852	Glioma	GDSC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation blocking phosphorylation signal	0.5
p.S1370C	ACH-000389	Brain Cancer	CCLE	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation blocking phosphorylation signal	0.5
p.S1370C	H4	central nervous system	COSMIC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation blocking phosphorylation signal	0.5
p.R850Q	SIDM00537	Colorectal Carcinoma	GDSC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation rewiring degron network	0.1944
p.R850Q	GP5d	large intestine	COSMIC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation rewiring degron network	0.1944
p.S1395L	SIDM00999	Bladder Carcinoma	GDSC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation blocking phosphorylation signal	0.5556
p.S1395L	ACH-000973	Bladder Cancer	CCLE	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation blocking phosphorylation signal	0.5556
p.S1395L	639-V	urinary tract	COSMIC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	1380:1387	Mutation blocking phosphorylation signal	0.5556
p.D861Y	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation altering degron motif	0.7325
p.D861Y	ACH-001127	Leukemia	CCLE	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation altering degron motif	0.7325
p.D861Y	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	KGFVHPD	LIG_APCC_ABBAyCdc20_2	855:861	Mutation altering degron motif	0.7325

Kaplan plot for NCAPD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCAPD2

UniProt ID: Q15021

Entrez ID: 9918

Protein name: Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCAPD2 in