DegronMD

Uniprot ID: Q15021

Source protein: Condensin complex subunit 1

Source gene: NCAPD2

Class: DEG_SCF_SKP2-CKS1_1

Location: 1380:1387

E3 ligase: SKP2,CSK1

DEGRON score: 0.9938

ASA_SCORE: 113.5375

COIL: 0.8379

CONS_SCORE: 0.3226

DSS_SCORE: 0.6731

HELIX: 0.1323

FCONS_SCORE: 1.0053

RIG_SCORE: 0.6819

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1384I	TCGA-91-6829	LUAD	TCGA	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.7078
p.T1384I	DO23564	LUAD	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.7078
p.A1394V	TCGA-L3-A4E7	LUSC	TCGA	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.1389
p.A1394V	DO45458	LUSC	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R1397C	DO230336	COCA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E1383K	DO222864	COCA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.591
p.E1383K	DO233823	GACA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.591
p.E1383K	SIDM01187	Breast Carcinoma	GDSC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.591
p.E1383K	SIDM00667	Other Sarcomas	GDSC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.591
p.K1386R	DO23428	LINC	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.6126
p.P1385S	DO220899	MELA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.6752
p.P1390S	DO220908	MELA	ICGC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.S1370C	SIDM00852	Glioma	GDSC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.5
p.S1370C	ACH-000389	Brain Cancer	CCLE	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.5
p.S1370C	H4	central_nervous_system	COSMIC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.5
p.S1395L	SIDM00999	Bladder Carcinoma	GDSC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.5556
p.S1395L	ACH-000973	Bladder Cancer	CCLE	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.5556
p.S1395L	639-V	urinary_tract	COSMIC	TEDETPKK	DEG_SCF_SKP2-CKS1_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15021	Condensin complex subunit 1	DEG_SCF_SKP2-CKS1_1	1380:1387	TEDETPKK	SKP2,CSK1	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons