DegronMD

Uniprot ID: Q9NR19

Source protein: Acetyl-coenzyme A synthetase, cytoplasmic

Source gene: ACSS2

Class: LIG_APCC_ABBAyCdc20_2

Location: 88:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5637

ASA_SCORE: 59.4857

COIL: 0.4663

CONS_SCORE: 0.2966

DSS_SCORE: 0.0505

HELIX: 0.0287

FCONS_SCORE: 0.9053

RIG_SCORE: 0.9566

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N83T	TCGA-AP-A051	UCEC	TCGA	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P78Q	TCGA-D3-A2JP	SKCM	TCGA	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.0556
p.W95L	DO234225	ESAD	ICGC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R81L	DO229029	LICA	ICGC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.1389
p.K88E	DO45263	LIRI	ICGC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.7022
p.R81W	DO220876	MELA	ICGC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L80F	SIDM00545	Melanoma	GDSC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L80F	ACH-000987	Skin Cancer	CCLE	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L80F	Mewo	skin	COSMIC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.1111
p.M96I	SIDM00091	Ovarian Carcinoma	GDSC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.2778
p.M96I	ACH-001151	Ovarian Cancer	CCLE	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.2778
p.M96I	OVCAR-5	ovary	COSMIC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR19	Acetyl-coenzyme A synthetase, cytoplasmic	LIG_APCC_ABBAyCdc20_2	88:94	KGKIFIE	APC,CDC20,FZR1	0.5637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons