DegronMD - Q9NR19(ACSS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N83T	TCGA-AP-A051	UCEC	TCGA	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1944
p.P78Q	TCGA-D3-A2JP	SKCM	TCGA	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0556
p.W95L	DO234225	ESAD	ICGC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.3056
p.R81L	DO229029	LICA	ICGC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1389
p.D35Y	DO229060	LICA	ICGC	SRSAHVPSL	DEG_COP1_1	36:44	Mutation rewiring degron network	0.3056
p.R52L	DO45045	LINC	ICGC	SRSAHVPSL	DEG_COP1_1	36:44	Mutation rewiring degron network	0.1111
p.K88E	DO45263	LIRI	ICGC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.7022
p.R81W	DO220876	MELA	ICGC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1389
p.P28Q	DO47407	SKCM	ICGC	SRSAHVPSL	DEG_COP1_1	36:44	Mutation blocking phosphorylation signal	0.5556
p.N33T	DO42673	UCEC	ICGC	SRSAHVPSL	DEG_COP1_1	36:44	Mutation rewiring degron network	0.25
p.L80F	SIDM00545	Melanoma	GDSC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1111
p.L80F	ACH-000987	Skin Cancer	CCLE	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1111
p.L80F	Mewo	skin	COSMIC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1111
p.M96I	SIDM00091	Ovarian Carcinoma	GDSC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.2778
p.M96I	ACH-001151	Ovarian Cancer	CCLE	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.2778
p.M96I	OVCAR-5	ovary	COSMIC	KGKIFIE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.2778
p.Y47N	ACH-000695	Lung Cancer	CCLE	SRSAHVPSL	DEG_COP1_1	36:44	Mutation blocking phosphorylation signal	0.6944
p.R27Q	ACH-000969	Colon/Colorectal Cancer	CCLE	SRSAHVPSL	DEG_COP1_1	36:44	Mutation rewiring degron network	0.0833

Kaplan plot for ACSS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACSS2

UniProt ID: Q9NR19

Entrez ID: 55902

Protein name: Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACSS2 in