DegronMD

Uniprot ID: Q9NR19

Source protein: Acetyl-coenzyme A synthetase, cytoplasmic

Source gene: ACSS2

Class: DEG_COP1_1

Location: 36:44

E3 ligase: COP1

DEGRON score: 0.844

ASA_SCORE: 61.9778

COIL: 0.6749

CONS_SCORE: 0.3302

DSS_SCORE: 0.4803

HELIX: 0.3122

FCONS_SCORE: 0.954

RIG_SCORE: 0.655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D35Y	DO229060	LICA	ICGC	SRSAHVPSL	DEG_COP1_1	0.3056
p.R52L	DO45045	LINC	ICGC	SRSAHVPSL	DEG_COP1_1	0.1111
p.P28Q	DO47407	SKCM	ICGC	SRSAHVPSL	DEG_COP1_1	0.5556
p.N33T	DO42673	UCEC	ICGC	SRSAHVPSL	DEG_COP1_1	0.25
p.Y47N	ACH-000695	Lung Cancer	CCLE	SRSAHVPSL	DEG_COP1_1	0.6944
p.R27Q	ACH-000969	Colon/Colorectal Cancer	CCLE	SRSAHVPSL	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR19	Acetyl-coenzyme A synthetase, cytoplasmic	DEG_COP1_1	36:44	SRSAHVPSL	COP1	0.844	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons