DegronMD

Uniprot ID: Q86UX6

Source protein: Serine/threonine-protein kinase 32C

Source gene: STK32C

Class: LIG_APCC_ABBAyCdc20_2

Location: 374:380

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9861

ASA_SCORE: 75.0857

COIL: 0.8713

CONS_SCORE: 0.5783

DSS_SCORE: 0.3296

HELIX: 0.0466

FCONS_SCORE: 0.9431

RIG_SCORE: 0.729

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G369S	DO10116	COAD	ICGC	KGRLHCD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G367W	DO37738	SKCM	ICGC	KGRLHCD	LIG_APCC_ABBAyCdc20_2	0.1389
p.M388L	TCGA-HD-7832	HNSC	TCGA	KGRLHCD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A366V	DO47700	SKCM	ICGC	KGRLHCD	LIG_APCC_ABBAyCdc20_2	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UX6	Serine/threonine-protein kinase 32C	LIG_APCC_ABBAyCdc20_2	374:380	KGRLHCD	APC,CDC20,FZR1	0.9861	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons