DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
KGRLHCD
Uniprot ID:
Q86UX6
Source protein:
Serine/threonine-protein kinase 32C
Source gene:
STK32C
Class:
LIG_APCC_ABBAyCdc20_2
Location:
374:380
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9861
ASA_SCORE:
75.0857
COIL:
0.8713
CONS_SCORE:
0.5783
DSS_SCORE:
0.3296
HELIX:
0.0466
FCONS_SCORE:
0.9431
RIG_SCORE:
0.729
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M388L
TCGA-HD-7832
HNSC
TCGA
KGRLHCD
LIG_APCC_ABBAyCdc20_2
0.1111
p.G369S
DO10116
COAD
ICGC
KGRLHCD
LIG_APCC_ABBAyCdc20_2
0.1944
p.G367W
DO37738
SKCM
ICGC
KGRLHCD
LIG_APCC_ABBAyCdc20_2
0.1389
p.A366V
DO47700
SKCM
ICGC
KGRLHCD
LIG_APCC_ABBAyCdc20_2
0.1111
Drug responses associated with STK32C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KGRLHCD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86UX6
Serine/threonine-protein kinase 32C
LIG_APCC_ABBAyCdc20_2
374:380
KGRLHCD
APC,CDC20,FZR1
0.9861
More...