DegronMD

Uniprot ID: P55884

Source protein: Eukaryotic translation initiation factor 3 subunit B

Source gene: EIF3B

Class: LIG_APCC_ABBAyCdc20_2

Location: 230:236

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7376

ASA_SCORE: 19.8857

COIL: 0.1217

CONS_SCORE: 0.5781

DSS_SCORE: 0.2269

HELIX: 0.0049

FCONS_SCORE: 1.3785

RIG_SCORE: 0.8732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P223H	TCGA-18-3416	LUSC	TCGA	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P223H	TCGA-BF-A1Q0	SKCM	TCGA	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P223H	DO26423	LUSC	ICGC	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P223H	DO47374	SKCM	ICGC	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A243D	TCGA-66-2778	LUSC	TCGA	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A243D	DO27548	LUSC	ICGC	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A238T	TCGA-A5-A0G2	UCEC	TCGA	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A238T	DO41235	UCEC	ICGC	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A238T	ACH-002069	Bone Cancer	CCLE	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A243T	TCGA-B5-A3FC	UCEC	TCGA	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A243T	DO41871	UCEC	ICGC	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.Y232C	TCGA-BR-8381	STAD	TCGA	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.7087
p.Y232C	DO47817	STAD	ICGC	KGYIFLE	LIG_APCC_ABBAyCdc20_2	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55884	Eukaryotic translation initiation factor 3 subunit B	LIG_APCC_ABBAyCdc20_2	230:236	KGYIFLE	APC,CDC20,FZR1	0.7376	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons