DegronMD

Uniprot ID: Q9ULL0

Source protein: Acrosomal protein KIAA1210

Source gene: KIAA1210

Class: LIG_APCC_ABBAyCdc20_2

Location: 1235:1241

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9931

ASA_SCORE: 116.8

COIL: 0.9321

CONS_SCORE: 0.44

DSS_SCORE: 0.6432

HELIX: 0.031

FCONS_SCORE: 0.8253

RIG_SCORE: 0.6804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1244I	TCGA-44-6777	LUAD	TCGA	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.S1244I	DO23645	LUAD	ICGC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.K1235Q	TCGA-61-1998	OV	TCGA	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.6944
p.K1235Q	DO28813	OV	ICGC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.6944
p.G1250R	TCGA-73-A9RS	LUAD	TCGA	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.G1250R	DO51193	LUAD	ICGC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q1237H	TCGA-AP-A1E0	UCEC	TCGA	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.647
p.Q1237H	DO43154	UCEC	ICGC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.647
p.S1230L	TCGA-AX-A2HC	UCEC	TCGA	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S1230L	DO41572	UCEC	ICGC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P1225S	TCGA-D3-A1QA	SKCM	TCGA	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P1225S	DO47469	SKCM	ICGC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q1237K	TCGA-ER-A2NF	SKCM	TCGA	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.5833
p.Q1237K	DO47451	SKCM	ICGC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.5833
p.P1232S	TCGA-EY-A1G8	UCEC	TCGA	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.P1232S	DO43578	UCEC	ICGC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.K1231N	TCGA-FB-AAPU	PAAD	TCGA	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.3333
p.K1231N	DO218966	PAAD	ICGC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.3333
p.P1247L	SIDM01175	Other Sarcomas	GDSC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P1247L	ACH-002309	Sarcoma	CCLE	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P1247L	SW684	soft_tissue	COSMIC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P1247S	SIDM01175	Other Sarcomas	GDSC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P1247S	ACH-002309	Sarcoma	CCLE	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P1247S	SW684	soft_tissue	COSMIC	KHQVFSD	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL0	Acrosomal protein KIAA1210	LIG_APCC_ABBAyCdc20_2	1235:1241	KHQVFSD	APC,CDC20,FZR1	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KHQVFSD

Degron related mutations and impact score

Drug responses associated with KIAA1210 mutations

All proteins holding degron of KHQVFSD