DegronMD

Uniprot ID: Q9BQ70

Source protein: Transcription factor 25

Source gene: TCF25

Class: LIG_APCC_ABBAyCdc20_2

Location: 175:181

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9047

ASA_SCORE: 59.7

COIL: 0.3093

CONS_SCORE: 0.4548

DSS_SCORE: 0.4296

HELIX: 0.3979

FCONS_SCORE: 1.1393

RIG_SCORE: 0.7591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S173P	TCGA-A5-A1OF	UCEC	TCGA	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.7222
p.S173P	DO42568	UCEC	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.7222
p.D188G	TCGA-BG-A222	UCEC	TCGA	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D188G	DO42977	UCEC	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P187L	TCGA-EE-A2GB	SKCM	TCGA	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P187L	DO37417	SKCM	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P187S	TCGA-FR-A728	SKCM	TCGA	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P187S	DO48550	SKCM	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S186C	DO475	BLCA	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A173G	DO234285	ESAD	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.7222
p.A190V	DO233203	GACA	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R166H	DO13462	GBM	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R166H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E172D	DO228986	LICA	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.6944
p.R166L	DO229006	LICA	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.0833
p.L177P	DO31400	OV	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.7582
p.Q169K	DO37896	SKCM	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S173F	SIDM00963	Breast Carcinoma	GDSC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.7222
p.S173F	ACH-000927	Breast Cancer	CCLE	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.7222
p.S173F	BT-474	breast	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.7222
p.L178F	SIDM00999	Bladder Carcinoma	GDSC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.6981
p.L178F	ACH-000973	Bladder Cancer	CCLE	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.6981
p.L178F	639-V	urinary_tract	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.6981
p.L180P	MCF7	breast	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQ70	Transcription factor 25	LIG_APCC_ABBAyCdc20_2	175:181	KHVLYVE	APC,CDC20,FZR1	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KHVLYVE

Degron related mutations and impact score

Drug responses associated with TCF25 mutations

All proteins holding degron of KHVLYVE