DegronMD - Q9BQ70(TCF25)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S173P	TCGA-A5-A1OF	UCEC	TCGA	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.S173P	DO42568	UCEC	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.E12G	TCGA-AD-5900	COAD	TCGA	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.2778
p.E12G	TCGA-BR-6452	STAD	TCGA	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.2778
p.E12G	DO8514	COAD	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.2778
p.E12G	DO38404	STAD	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.2778
p.R209K	TCGA-AP-A1DV	UCEC	TCGA	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.0556
p.R209K	DO43186	UCEC	ICGC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.0556
p.S235F	TCGA-BF-AAP2	SKCM	TCGA	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation blocking phosphorylation signal	0.5
p.S235F	DO219466	SKCM	ICGC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation blocking phosphorylation signal	0.5
p.D188G	TCGA-BG-A222	UCEC	TCGA	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1389
p.D188G	DO42977	UCEC	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1389
p.L234V	TCGA-DD-A1EB	LIHC	TCGA	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.0833
p.P187L	TCGA-EE-A2GB	SKCM	TCGA	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1667
p.P187L	DO37417	SKCM	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1667
p.S230I	TCGA-EY-A215	UCEC	TCGA	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.1944
p.S230I	DO42665	UCEC	ICGC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.1944
p.P187S	TCGA-FR-A728	SKCM	TCGA	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1667
p.P187S	DO48550	SKCM	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1667
p.S186C	DO475	BLCA	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1944
p.G225E	DO44258	BRCA	ICGC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation altering degron motif	0.7199
p.S235T	DO7934	COAD	ICGC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation blocking phosphorylation signal	0.5
p.A173G	DO234285	ESAD	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.A190V	DO233203	GACA	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.0833
p.R166H	DO13462	GBM	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.0833
p.R166H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.0833
p.E172D	DO228986	LICA	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6944
p.R166L	DO229006	LICA	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.0833
p.L177P	DO31400	OV	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.7582
p.Q169K	DO37896	SKCM	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation rewiring degron network	0.1667
p.K7N	DO229229	THCA	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6918
p.L4P	DO229242	THCA	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.7582
p.G9S	DO42953	UCEC	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6993
p.S213F	DO43907	UCEC	ICGC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.1667
p.R2W	DO43891	UCEC	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.8634
p.R3H	SIDM00373	Endometrial Carcinoma	GDSC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.8244
p.R3H	ACH-000974	Endometrial/Uterine Cancer	CCLE	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.8244
p.R228C	SIDM00296	Small Cell Lung Carcinoma	GDSC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.25
p.R228C	SIDM00383	Gastric Carcinoma	GDSC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.25
p.R228C	ACH-002051	Lung Cancer	CCLE	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.25
p.R228C	ACH-002198	Gastric Cancer	CCLE	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.25
p.R228C	SCH	stomach	COSMIC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.25
p.R228C	LU-134-A	lung	COSMIC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.25
p.S173F	SIDM00963	Breast Carcinoma	GDSC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.S173F	ACH-000927	Breast Cancer	CCLE	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.S173F	BT-474	breast	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.L178F	SIDM00999	Bladder Carcinoma	GDSC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6981
p.L178F	ACH-000973	Bladder Cancer	CCLE	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6981
p.L178F	639-V	urinary tract	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6981
p.R228H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.25
p.R228H	ACH-001127	Leukemia	CCLE	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.25
p.R228H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.25
p.P227L	ACH-000050	Myeloma	CCLE	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.2778
p.P227S	ACH-000629	Brain Cancer	CCLE	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.2778
p.L180P	MCF7	breast	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.7582
p.A219V	HCT-15	large intestine	COSMIC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF25

UniProt ID: Q9BQ70

Entrez ID: 22980

Protein name: Transcription factor 25 (TCF-25) (Nuclear localized protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF25 in