DegronMD - Q9BQ70(TCF25)

FUNCTION: May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. {ECO:0000269|PubMed:16574069}.

GO - Biological processes (BP): heart development [GO:0007507]; negative regulation of transcription by RNA polymerase II [GO:0000122]

GO - Molecular function (MF): DNA binding [GO:0003677]; transcription corepressor activity [GO:0003714]

GO - Cellular component (CC): nucleus [GO:0005634]; RQC complex [GO:1990112]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2W	DO43891	UCEC	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.8634
p.R3H	SIDM00373	Endometrial Carcinoma	GDSC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.8244
p.R3H	ACH-000974	Endometrial/Uterine Cancer	CCLE	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.8244
p.L177P	DO31400	OV	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.7582
p.L4P	DO229242	THCA	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.7582
p.L180P	MCF7	breast	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.7582
p.S173P	TCGA-A5-A1OF	UCEC	TCGA	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.S173P	DO42568	UCEC	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.A173G	DO234285	ESAD	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.S173F	SIDM00963	Breast Carcinoma	GDSC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.S173F	ACH-000927	Breast Cancer	CCLE	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.S173F	BT-474	breast	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.7222
p.G225E	DO44258	BRCA	ICGC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation altering degron motif	0.7199
p.G9S	DO42953	UCEC	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6993
p.L178F	SIDM00999	Bladder Carcinoma	GDSC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6981
p.L178F	ACH-000973	Bladder Cancer	CCLE	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6981
p.L178F	639-V	urinary tract	COSMIC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation altering degron motif	0.6981
p.E172D	DO228986	LICA	ICGC	KHVLYVE	LIG_APCC_ABBAyCdc20_2	175:181	Mutation blocking phosphorylation signal	0.6944
p.A219V	HCT-15	large intestine	COSMIC	LTTPKST	DEG_SCF_FBW7_1	219:225	Mutation altering degron motif	0.6936
p.K7N	DO229229	THCA	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6918

Showing 1 to 20 of 56 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCF25

UniProt ID: Q9BQ70

Entrez ID: 22980

Protein name: Transcription factor 25 (TCF-25) (Nuclear localized protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCF25 in