DegronMD

Uniprot ID: Q9BQ70

Source protein: Transcription factor 25

Source gene: TCF25

Class: DEG_APCC_DBOX_1

Location: 2:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9817

ASA_SCORE: 94.6667

COIL: 0.3676

CONS_SCORE: 0.6189

DSS_SCORE: 0.7891

HELIX: 0.6138

FCONS_SCORE: 1.9228

RIG_SCORE: 0.7361

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E12G	TCGA-AD-5900	COAD	TCGA	SRRALRRLR	DEG_APCC_DBOX_1	0.2778
p.E12G	TCGA-BR-6452	STAD	TCGA	SRRALRRLR	DEG_APCC_DBOX_1	0.2778
p.E12G	DO8514	COAD	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	0.2778
p.E12G	DO38404	STAD	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	0.2778
p.K7N	DO229229	THCA	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	0.6918
p.L4P	DO229242	THCA	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	0.7582
p.G9S	DO42953	UCEC	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	0.6993
p.R2W	DO43891	UCEC	ICGC	SRRALRRLR	DEG_APCC_DBOX_1	0.8634
p.R3H	SIDM00373	Endometrial Carcinoma	GDSC	SRRALRRLR	DEG_APCC_DBOX_1	0.8244
p.R3H	ACH-000974	Endometrial/Uterine Cancer	CCLE	SRRALRRLR	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQ70	Transcription factor 25	DEG_APCC_DBOX_1	2:10	SRRALRRLR	APC,CDC20,FZR1	0.9817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons