DegronMD

Uniprot ID: Q9BQ70

Source protein: Transcription factor 25

Source gene: TCF25

Class: DEG_SCF_FBW7_1

Location: 219:225

E3 ligase: FBXW7

DEGRON score: 0.9966

ASA_SCORE: 83.7

COIL: 0.9207

CONS_SCORE: 0.4215

DSS_SCORE: 0.3455

HELIX: 0.0206

FCONS_SCORE: 1.0698

RIG_SCORE: 0.7867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R209K	TCGA-AP-A1DV	UCEC	TCGA	LTTPKST	DEG_SCF_FBW7_1	0.0556
p.R209K	DO43186	UCEC	ICGC	LTTPKST	DEG_SCF_FBW7_1	0.0556
p.S235F	TCGA-BF-AAP2	SKCM	TCGA	LTTPKST	DEG_SCF_FBW7_1	0.5
p.S235F	DO219466	SKCM	ICGC	LTTPKST	DEG_SCF_FBW7_1	0.5
p.L234V	TCGA-DD-A1EB	LIHC	TCGA	LTTPKST	DEG_SCF_FBW7_1	0.0833
p.S230I	TCGA-EY-A215	UCEC	TCGA	LTTPKST	DEG_SCF_FBW7_1	0.1944
p.S230I	DO42665	UCEC	ICGC	LTTPKST	DEG_SCF_FBW7_1	0.1944
p.G225E	DO44258	BRCA	ICGC	LTTPKST	DEG_SCF_FBW7_1	0.7199
p.S235T	DO7934	COAD	ICGC	LTTPKST	DEG_SCF_FBW7_1	0.5
p.S213F	DO43907	UCEC	ICGC	LTTPKST	DEG_SCF_FBW7_1	0.1667
p.R228C	SIDM00296	Small Cell Lung Carcinoma	GDSC	LTTPKST	DEG_SCF_FBW7_1	0.25
p.R228C	SIDM00383	Gastric Carcinoma	GDSC	LTTPKST	DEG_SCF_FBW7_1	0.25
p.R228C	ACH-002051	Lung Cancer	CCLE	LTTPKST	DEG_SCF_FBW7_1	0.25
p.R228C	ACH-002198	Gastric Cancer	CCLE	LTTPKST	DEG_SCF_FBW7_1	0.25
p.R228C	SCH	stomach	COSMIC	LTTPKST	DEG_SCF_FBW7_1	0.25
p.R228C	LU-134-A	lung	COSMIC	LTTPKST	DEG_SCF_FBW7_1	0.25
p.R228H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LTTPKST	DEG_SCF_FBW7_1	0.25
p.R228H	ACH-001127	Leukemia	CCLE	LTTPKST	DEG_SCF_FBW7_1	0.25
p.R228H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPKST	DEG_SCF_FBW7_1	0.25
p.P227L	ACH-000050	Myeloma	CCLE	LTTPKST	DEG_SCF_FBW7_1	0.2778
p.P227S	ACH-000629	Brain Cancer	CCLE	LTTPKST	DEG_SCF_FBW7_1	0.2778
p.A219V	HCT-15	large_intestine	COSMIC	LTTPKST	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQ70	Transcription factor 25	DEG_SCF_FBW7_1	219:225	LTTPKST	FBXW7	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons