DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
KIDSTPVK
Uniprot ID:
Q92928
Source protein:
Putative Ras-related protein Rab-1C
Source gene:
RAB1C
Class:
DEG_SCF_SKP2-CKS1_1
Location:
187:194
E3 ligase:
SKP2,CSK1
DEGRON score:
0.9794
ASA_SCORE:
102.9
COIL:
0.9224
CONS_SCORE:
0.4303
DSS_SCORE:
0.5925
HELIX:
0.0196
FCONS_SCORE:
0.9677
RIG_SCORE:
0.7022
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RAB1C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KIDSTPVK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H0U4
Ras-related protein Rab-1B
DEG_SCF_SKP2-CKS1_1
187:194
KIDSTPVK
SKP2,CSK1
0.9943
More...
Q92928
Putative Ras-related protein Rab-1C
DEG_SCF_SKP2-CKS1_1
187:194
KIDSTPVK
SKP2,CSK1
0.9794
More...