DegronMD

Uniprot ID: Q9H0V9

Source protein: VIP36-like protein

Source gene: LMAN2L

Class: LIG_APCC_ABBAyCdc20_2

Location: 122:128

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.814

ASA_SCORE: 79.4571

COIL: 0.781

CONS_SCORE: 0.4904

DSS_SCORE: 0.2009

HELIX: 0.0796

FCONS_SCORE: 0.8001

RIG_SCORE: 0.7231

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G121A	TCGA-3A-A9IU	PAAD	TCGA	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K136M	TCGA-86-8279	LUAD	TCGA	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Y134C	TCGA-94-7557	LUSC	TCGA	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R138L	TCGA-BF-A1PZ	SKCM	TCGA	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.K123N	TCGA-BS-A0TC	UCEC	TCGA	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.5806
p.F115L	TCGA-EY-A1G8	UCEC	TCGA	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.F115L	DO43578	UCEC	ICGC	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.L131F	DO44038	BLCA	ICGC	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.I117V	DO233831	GACA	ICGC	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.H118N	DO229045	LICA	ICGC	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D131N	DO24940	LUAD	ICGC	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.D127A	DO42673	UCEC	ICGC	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.7793
p.G129S	SIDM00113	Kidney Carcinoma	GDSC	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G129S	ACH-001208	Kidney Cancer	CCLE	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G129S	TK10	kidney	COSMIC	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.V113G	ACH-000463	Lung Cancer	CCLE	KKNLHGD	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0V9	VIP36-like protein	LIG_APCC_ABBAyCdc20_2	122:128	KKNLHGD	APC,CDC20,FZR1	0.814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons