DegronMD

Uniprot ID: Q5U623

Source protein: Activating transcription factor 7-interacting protein 2

Source gene: ATF7IP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 283:289

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6009

ASA_SCORE: 111.0571

COIL: 0.6096

CONS_SCORE: 0.5697

DSS_SCORE: 0.5338

HELIX: 0.1833

FCONS_SCORE: 1.0607

RIG_SCORE: 0.7339

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N278S	TCGA-27-1838	GBM	TCGA	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.N278S	DO12154	GBM	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K283N	TCGA-E6-A1M0	UCEC	TCGA	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K283N	DO43682	UCEC	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.6918
p.E292K	TCGA-GN-A269	SKCM	TCGA	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.E292K	DO37483	SKCM	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R285M	DO229019	LICA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.7521
p.E291K	DO220877	MELA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E291K	DO222843	MELA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.N293K	DO229253	THCA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N277D	DO229250	THCA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S279R	SIDM01265	Plasma Cell Myeloma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.6667
p.S279R	SIDM00257	Neuroblastoma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.6667
p.R296C	SIDM00120	Prostate Carcinoma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R296C	SIDM00487	Colorectal Carcinoma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R296C	ACH-000963	Colon/Colorectal Cancer	CCLE	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R296C	ACH-000979	Prostate Cancer	CCLE	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R296C	DU-145	prostate	COSMIC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R296C	CCK-81	large_intestine	COSMIC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.M286I	SIDM00493	Other Solid Cancers	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.6507
p.M286I	SIDM00793	Burkitt's Lymphoma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5U623	Activating transcription factor 7-interacting protein 2	LIG_APCC_ABBAyCdc20_2	283:289	KKRMFSE	APC,CDC20,FZR1	0.6009	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons