DegronMD - Q5U623(ATF7IP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N278S	TCGA-27-1838	GBM	TCGA	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.1944
p.N278S	DO12154	GBM	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.1944
p.S460Y	TCGA-A5-A0G2	UCEC	TCGA	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.1667
p.S460Y	TCGA-EO-A3B0	UCEC	TCGA	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.1667
p.S460Y	DO219773	UCEC	ICGC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.1667
p.S460Y	DO41235	UCEC	ICGC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.1667
p.S460F	TCGA-B5-A11N	UCEC	TCGA	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.1667
p.S460F	DO41458	UCEC	ICGC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.1667
p.K283N	TCGA-E6-A1M0	UCEC	TCGA	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation altering degron motif	0.6918
p.K283N	DO43682	UCEC	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation altering degron motif	0.6918
p.E292K	TCGA-GN-A269	SKCM	TCGA	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.25
p.E292K	DO37483	SKCM	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.25
p.L458F	DO228974	LICA	ICGC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.1111
p.R285M	DO229019	LICA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation altering degron motif	0.7521
p.R478I	DO229037	LICA	ICGC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.1667
p.K479N	DO228371	MALY	ICGC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation substituting flanking lysine	0.25
p.K479N	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation substituting flanking lysine	0.25
p.K479N	ACH-000315	Lymphoma	CCLE	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation substituting flanking lysine	0.25
p.K479N	KARPAS-422	haematopoietic and lymphoid tissue	COSMIC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation substituting flanking lysine	0.25
p.E291K	DO220877	MELA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.2778
p.E291K	DO222843	MELA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.2778
p.N293K	DO229253	THCA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.2222
p.N277D	DO229250	THCA	ICGC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.1667
p.S279R	SIDM01265	Plasma Cell Myeloma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation blocking phosphorylation signal	0.6667
p.S279R	SIDM00257	Neuroblastoma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation blocking phosphorylation signal	0.6667
p.V456D	SIDM00717	Non-Cancerous	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00915	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00652	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM01087	Melanoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM01201	Other Blood Cancers	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00917	Acute Myeloid Leukemia	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00142	Endometrial Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00733	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00995	Other Solid Cancers	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00779	Colorectal Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00183	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00154	Mesothelioma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM01648	Non-Cancerous	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00760	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM00490	Glioma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM01635	Glioblastoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.V456D	SIDM01525	Acute Myeloid Leukemia	GDSC	LTTPITS	DEG_SCF_FBW7_1	466:472	Mutation rewiring degron network	0.0556
p.R296C	SIDM00120	Prostate Carcinoma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.1389
p.R296C	SIDM00487	Colorectal Carcinoma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.1389
p.R296C	ACH-000963	Colon/Colorectal Cancer	CCLE	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.1389
p.R296C	ACH-000979	Prostate Cancer	CCLE	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.1389
p.R296C	DU-145	prostate	COSMIC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.1389
p.R296C	CCK-81	large intestine	COSMIC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation rewiring degron network	0.1389
p.M286I	SIDM00493	Other Solid Cancers	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation altering degron motif	0.6507
p.M286I	SIDM00793	Burkitt's Lymphoma	GDSC	KKRMFSE	LIG_APCC_ABBAyCdc20_2	283:289	Mutation altering degron motif	0.6507

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATF7IP2

UniProt ID: Q5U623

Entrez ID: 80063

Protein name: Activating transcription factor 7-interacting protein 2 (ATF7-interacting protein 2) (MBD1-containing chromatin-associated factor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATF7IP2 in