DegronMD

Uniprot ID: Q5U623

Source protein: Activating transcription factor 7-interacting protein 2

Source gene: ATF7IP2

Class: DEG_SCF_FBW7_1

Location: 466:472

E3 ligase: FBXW7

DEGRON score: 0.7319

ASA_SCORE: 82.2714

COIL: 0.8411

CONS_SCORE: 0.5606

DSS_SCORE: 0.597

HELIX: 0.021

FCONS_SCORE: 0.9809

RIG_SCORE: 0.6802

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S460Y	TCGA-A5-A0G2	UCEC	TCGA	LTTPITS	DEG_SCF_FBW7_1	0.1667
p.S460Y	TCGA-EO-A3B0	UCEC	TCGA	LTTPITS	DEG_SCF_FBW7_1	0.1667
p.S460Y	DO219773	UCEC	ICGC	LTTPITS	DEG_SCF_FBW7_1	0.1667
p.S460Y	DO41235	UCEC	ICGC	LTTPITS	DEG_SCF_FBW7_1	0.1667
p.S460F	TCGA-B5-A11N	UCEC	TCGA	LTTPITS	DEG_SCF_FBW7_1	0.1667
p.S460F	DO41458	UCEC	ICGC	LTTPITS	DEG_SCF_FBW7_1	0.1667
p.L458F	DO228974	LICA	ICGC	LTTPITS	DEG_SCF_FBW7_1	0.1111
p.R478I	DO229037	LICA	ICGC	LTTPITS	DEG_SCF_FBW7_1	0.1667
p.K479N	DO228371	MALY	ICGC	LTTPITS	DEG_SCF_FBW7_1	0.25
p.K479N	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.25
p.K479N	ACH-000315	Lymphoma	CCLE	LTTPITS	DEG_SCF_FBW7_1	0.25
p.K479N	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPITS	DEG_SCF_FBW7_1	0.25
p.V456D	SIDM00717	Non-Cancerous	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00915	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00652	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM01087	Melanoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM01201	Other Blood Cancers	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00917	Acute Myeloid Leukemia	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00142	Endometrial Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00733	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00995	Other Solid Cancers	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00779	Colorectal Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00183	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00154	Mesothelioma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM01648	Non-Cancerous	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00760	Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM00490	Glioma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM01635	Glioblastoma	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556
p.V456D	SIDM01525	Acute Myeloid Leukemia	GDSC	LTTPITS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTTPITS

Degron related mutations and impact score

Drug responses associated with ATF7IP2 mutations

All proteins holding degron of LTTPITS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5U623	Activating transcription factor 7-interacting protein 2	DEG_SCF_FBW7_1	466:472	LTTPITS	FBXW7	0.7319	More...