DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
KKTVHFD
Uniprot ID:
Q9P260
Source protein:
RAB11-binding protein RELCH
Source gene:
RELCH
Class:
LIG_APCC_ABBAyCdc20_2
Location:
473:479
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.908
ASA_SCORE:
95.3143
COIL:
0.7416
CONS_SCORE:
0.3233
DSS_SCORE:
0.6034
HELIX:
0.0791
FCONS_SCORE:
0.8426
RIG_SCORE:
0.6827
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RELCH mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KKTVHFD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P260
RAB11-binding protein RELCH
LIG_APCC_ABBAyCdc20_2
473:479
KKTVHFD
APC,CDC20,FZR1
0.908
More...