DegronMD

Uniprot ID: O75449

Source protein: Katanin p60 ATPase-containing subunit A1

Source gene: KATNA1

Class: DEG_SCF_SKP2-CKS1_1

Location: 77:84

E3 ligase: SKP2,CSK1

DEGRON score: 0.9799

ASA_SCORE: 101.8

COIL: 0.7965

CONS_SCORE: 0.327

DSS_SCORE: 0.4028

HELIX: 0.1839

FCONS_SCORE: 0.8128

RIG_SCORE: 0.7481

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D89E	TCGA-12-0778	GBM	TCGA	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.D89E	DO11411	GBM	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E94D	TCGA-4Z-AA7O	BLCA	TCGA	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E94D	DO51865	BLCA	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E94Q	TCGA-4Z-AA7W	BLCA	TCGA	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E94Q	DO218984	BLCA	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E94Q	ACH-001699	Head and Neck Cancer	CCLE	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E94G	TCGA-HU-A4GT	STAD	TCGA	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E94G	DO48020	STAD	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P82L	TCGA-YD-A89C	SKCM	TCGA	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P82L	DO219501	SKCM	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.7582
p.D79H	TCGA-ZF-AA54	BLCA	TCGA	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.7688
p.D79H	DO219098	BLCA	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.7688
p.H88N	DO228976	LICA	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.2222
p.A85E	DO229034	LICA	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.S75I	DO233295	NACA	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.2778
p.A86T	DO233299	NACA	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.2778
p.H88R	DO229253	THCA	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.2222
p.A85S	DO229232	THCA	ICGC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A85V	SIDM00379	Glioma	GDSC	KLDSTPLK	DEG_SCF_SKP2-CKS1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75449	Katanin p60 ATPase-containing subunit A1	DEG_SCF_SKP2-CKS1_1	77:84	KLDSTPLK	SKP2,CSK1	0.9799	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons