DegronMD

Uniprot ID: Q8TCF1

Source protein: AN1-type zinc finger protein 1

Source gene: ZFAND1

Class: LIG_APCC_ABBAyCdc20_2

Location: 147:153

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6797

ASA_SCORE: 94.0857

COIL: 0.4889

CONS_SCORE: 0.5027

DSS_SCORE: 0.3852

HELIX: 0.4217

FCONS_SCORE: 1.127

RIG_SCORE: 0.7682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E138K	TCGA-21-1071	LUSC	TCGA	KLKMHAD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S137I	TCGA-AP-A1DK	UCEC	TCGA	KLKMHAD	LIG_APCC_ABBAyCdc20_2	0.0556
p.S137I	DO42033	UCEC	ICGC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	0.0556
p.H151N	DO229038	LICA	ICGC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	0.7423
p.Q151K	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	0.6944
p.F162V	SNU-81	large_intestine	COSMIC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E157K	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCF1	AN1-type zinc finger protein 1	LIG_APCC_ABBAyCdc20_2	147:153	KLKMHAD	APC,CDC20,FZR1	0.6797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons