DegronMD - Q8TCF1(ZFAND1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E138K	TCGA-21-1071	LUSC	TCGA	LKMHAD	LIG_APCC_ABBA_1	148:153	Mutation rewiring degron network	0.0556
p.E138K	TCGA-21-1071	LUSC	TCGA	KLKMHAD	LIG_APCC_ABBAyCdc20_2	147:153	Mutation rewiring degron network	0.0833
p.S137I	TCGA-AP-A1DK	UCEC	TCGA	KLKMHAD	LIG_APCC_ABBAyCdc20_2	147:153	Mutation rewiring degron network	0.0556
p.S137I	DO42033	UCEC	ICGC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	147:153	Mutation rewiring degron network	0.0556
p.H151N	DO229038	LICA	ICGC	LKMHAD	LIG_APCC_ABBA_1	148:153	Mutation altering degron motif	0.7423
p.H151N	DO229038	LICA	ICGC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	147:153	Mutation altering degron motif	0.7423
p.Q151K	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	LKMHAD	LIG_APCC_ABBA_1	148:153	Mutation altering degron motif	0.6944
p.Q151K	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	147:153	Mutation altering degron motif	0.6944
p.F162V	SNU-81	large intestine	COSMIC	LKMHAD	LIG_APCC_ABBA_1	148:153	Mutation rewiring degron network	0.0833
p.F162V	SNU-81	large intestine	COSMIC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	147:153	Mutation rewiring degron network	0.0833
p.E157K	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	LKMHAD	LIG_APCC_ABBA_1	148:153	Mutation rewiring degron network	0.2222
p.E157K	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	KLKMHAD	LIG_APCC_ABBAyCdc20_2	147:153	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons