DegronMD

Uniprot ID: Q8TCF1

Source protein: AN1-type zinc finger protein 1

Source gene: ZFAND1

Class: LIG_APCC_ABBA_1

Location: 148:153

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.608

ASA_SCORE: 89.15

COIL: 0.518

CONS_SCORE: 0.5001

DSS_SCORE: 0.3838

HELIX: 0.3827

FCONS_SCORE: 1.0981

RIG_SCORE: 0.7607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E138K	TCGA-21-1071	LUSC	TCGA	LKMHAD	LIG_APCC_ABBA_1	0.0556
p.H151N	DO229038	LICA	ICGC	LKMHAD	LIG_APCC_ABBA_1	0.7423
p.Q151K	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	LKMHAD	LIG_APCC_ABBA_1	0.6944
p.F162V	SNU-81	large_intestine	COSMIC	LKMHAD	LIG_APCC_ABBA_1	0.0833
p.E157K	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	LKMHAD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCF1	AN1-type zinc finger protein 1	LIG_APCC_ABBA_1	148:153	LKMHAD	APC,CDC20,FZR1	0.608	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons