DegronMD

Uniprot ID: Q6YHK3

Source protein: CD109 antigen

Source gene: CD109

Class: LIG_APCC_ABBAyCdc20_2

Location: 1346:1352

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5109

ASA_SCORE: 23.0429

COIL: 0.1069

CONS_SCORE: 0.5077

DSS_SCORE: 0.1348

HELIX: 0.0054

FCONS_SCORE: 1.3134

RIG_SCORE: 0.8605

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1344Y	TCGA-D3-A8GI	SKCM	TCGA	KLNLYLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.H1344Y	DO50284	SKCM	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D1352Y	DO222884	COCA	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	0.7325
p.V1337L	DO228948	LICA	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D1343Y	DO229009	LICA	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	0.25
p.V1361F	DO229009	LICA	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.N1348K	DO51965	PRAD	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	0.5806
p.C1336F	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6YHK3	CD109 antigen	LIG_APCC_ABBAyCdc20_2	1346:1352	KLNLYLD	APC,CDC20,FZR1	0.5109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons