DegronMD - Q6YHK3(CD109)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H1344Y	TCGA-D3-A8GI	SKCM	TCGA	LNLYLD	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.25
p.H1344Y	TCGA-D3-A8GI	SKCM	TCGA	KLNLYLD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.2778
p.H1344Y	DO50284	SKCM	ICGC	LNLYLD	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.25
p.H1344Y	DO50284	SKCM	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.2778
p.D1352Y	DO222884	COCA	ICGC	LNLYLD	LIG_APCC_ABBA_1	1347:1352	Mutation altering degron motif	0.7325
p.D1352Y	DO222884	COCA	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation altering degron motif	0.7325
p.V1337L	DO228948	LICA	ICGC	LNLYLD	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.0556
p.V1337L	DO228948	LICA	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.0833
p.D1343Y	DO229009	LICA	ICGC	LNLYLD	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.2222
p.D1343Y	DO229009	LICA	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.25
p.V1361F	DO229009	LICA	ICGC	LNLYLD	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.0833
p.V1361F	DO229009	LICA	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.0833
p.N1348K	DO51965	PRAD	ICGC	LNLYLD	LIG_APCC_ABBA_1	1347:1352	Mutation altering degron motif	0.5806
p.N1348K	DO51965	PRAD	ICGC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation altering degron motif	0.5806
p.C1336F	KP-N-RT-BM-1	autonomic ganglia	COSMIC	KLNLYLD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.0556

Kaplan plot for CD109 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD109

UniProt ID: Q6YHK3

Entrez ID: 135228

Protein name: CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD109 in