DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LNLYLD
Uniprot ID:
Q6YHK3
Source protein:
CD109 antigen
Source gene:
CD109
Class:
LIG_APCC_ABBA_1
Location:
1347:1352
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5109
ASA_SCORE:
14.55
COIL:
0.1233
CONS_SCORE:
0.534
DSS_SCORE:
0.1324
HELIX:
0.0063
FCONS_SCORE:
1.3916
RIG_SCORE:
0.8665
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H1344Y
TCGA-D3-A8GI
SKCM
TCGA
LNLYLD
LIG_APCC_ABBA_1
0.25
p.H1344Y
DO50284
SKCM
ICGC
LNLYLD
LIG_APCC_ABBA_1
0.25
p.D1352Y
DO222884
COCA
ICGC
LNLYLD
LIG_APCC_ABBA_1
0.7325
p.V1337L
DO228948
LICA
ICGC
LNLYLD
LIG_APCC_ABBA_1
0.0556
p.D1343Y
DO229009
LICA
ICGC
LNLYLD
LIG_APCC_ABBA_1
0.2222
p.V1361F
DO229009
LICA
ICGC
LNLYLD
LIG_APCC_ABBA_1
0.0833
p.N1348K
DO51965
PRAD
ICGC
LNLYLD
LIG_APCC_ABBA_1
0.5806
Drug responses associated with CD109 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LNLYLD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6YHK3
CD109 antigen
LIG_APCC_ABBA_1
1347:1352
LNLYLD
APC,CDC20,FZR1
0.5109
More...