DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KLSIYGD
Uniprot ID:
Q9BXS4
Source protein:
Transmembrane protein 59
Source gene:
TMEM59
Class:
LIG_APCC_ABBAyCdc20_2
Location:
273:279
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6046
ASA_SCORE:
65.7143
COIL:
0.7246
CONS_SCORE:
0.702
DSS_SCORE:
0.104
HELIX:
0.163
FCONS_SCORE:
1.4352
RIG_SCORE:
0.875
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y277C
DO222919
BTCA
ICGC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.8198
p.L274Q
DO46546
OV
ICGC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.6654
p.G278R
SIDM00844
Burkitt's Lymphoma
GDSC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.6457
p.G278R
ACH-000654
Lymphoma
CCLE
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.6457
p.G278R
Raji
haematopoietic_and_lymphoid_tissue
COSMIC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.6457
p.G278S
DO229208
THCA
ICGC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.5882
p.S271Y
TCGA-80-5608
LUAD
TCGA
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.2778
p.S271Y
DO23693
LUAD
ICGC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.2778
p.M283I
TCGA-AX-A0J0
UCEC
TCGA
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.2222
p.M283I
DO41133
UCEC
ICGC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.2222
p.M283I
SIDM00588
Oral Cavity Carcinoma
GDSC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.2222
p.M283I
ACH-000546
Head and Neck Cancer
CCLE
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.2222
p.M283I
HSC-4
upper_aerodigestive_tract
COSMIC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.2222
p.A264S
TCGA-AP-A051
UCEC
TCGA
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.0833
p.A264S
DO42673
UCEC
ICGC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.0833
p.A264V
TCGA-B5-A1MX
UCEC
TCGA
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.0833
p.A264V
DO41999
UCEC
ICGC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.0833
p.A264D
DO229029
LICA
ICGC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.0833
p.N289K
DO229036
LICA
ICGC
KLSIYGD
LIG_APCC_ABBAyCdc20_2
0.0556
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Drug responses associated with TMEM59 mutations
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Cancer
Mutation (In Degron?)
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Drug
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All proteins holding degron of KLSIYGD
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BXS4
Transmembrane protein 59
LIG_APCC_ABBAyCdc20_2
273:279
KLSIYGD
APC,CDC20,FZR1
0.6046
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