DegronMD - Q9BXS4(TMEM59)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S271Y	TCGA-80-5608	LUAD	TCGA	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.25
p.S271Y	TCGA-80-5608	LUAD	TCGA	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.2778
p.S271Y	DO23693	LUAD	ICGC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.25
p.S271Y	DO23693	LUAD	ICGC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.2778
p.A264S	TCGA-AP-A051	UCEC	TCGA	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0556
p.A264S	TCGA-AP-A051	UCEC	TCGA	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.0833
p.A264S	DO42673	UCEC	ICGC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0556
p.A264S	DO42673	UCEC	ICGC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.0833
p.M283I	TCGA-AX-A0J0	UCEC	TCGA	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.2222
p.M283I	TCGA-AX-A0J0	UCEC	TCGA	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.2222
p.M283I	DO41133	UCEC	ICGC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.2222
p.M283I	DO41133	UCEC	ICGC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.2222
p.M283I	SIDM00588	Oral Cavity Carcinoma	GDSC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.2222
p.M283I	SIDM00588	Oral Cavity Carcinoma	GDSC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.2222
p.M283I	ACH-000546	Head and Neck Cancer	CCLE	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.2222
p.M283I	ACH-000546	Head and Neck Cancer	CCLE	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.2222
p.M283I	HSC-4	upper aerodigestive tract	COSMIC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.2222
p.M283I	HSC-4	upper aerodigestive tract	COSMIC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.2222
p.A264V	TCGA-B5-A1MX	UCEC	TCGA	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0556
p.A264V	TCGA-B5-A1MX	UCEC	TCGA	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.0833
p.A264V	DO41999	UCEC	ICGC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0556
p.A264V	DO41999	UCEC	ICGC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.0833
p.Y277C	DO222919	BTCA	ICGC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation altering degron motif	0.8198
p.Y277C	DO222919	BTCA	ICGC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation altering degron motif	0.8198
p.A264D	DO229029	LICA	ICGC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0556
p.A264D	DO229029	LICA	ICGC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.0833
p.N289K	DO229036	LICA	ICGC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation rewiring degron network	0.0556
p.N289K	DO229036	LICA	ICGC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation rewiring degron network	0.0556
p.L274Q	DO46546	OV	ICGC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation altering degron motif	0.7765
p.L274Q	DO46546	OV	ICGC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation altering degron motif	0.6654
p.G278S	DO229208	THCA	ICGC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation altering degron motif	0.5882
p.G278S	DO229208	THCA	ICGC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation altering degron motif	0.5882
p.G278R	SIDM00844	Burkitt's Lymphoma	GDSC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation altering degron motif	0.6457
p.G278R	SIDM00844	Burkitt's Lymphoma	GDSC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation altering degron motif	0.6457
p.G278R	ACH-000654	Lymphoma	CCLE	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation altering degron motif	0.6457
p.G278R	ACH-000654	Lymphoma	CCLE	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation altering degron motif	0.6457
p.G278R	Raji	haematopoietic and lymphoid tissue	COSMIC	LSIYGD	LIG_APCC_ABBA_1	274:279	Mutation altering degron motif	0.6457
p.G278R	Raji	haematopoietic and lymphoid tissue	COSMIC	KLSIYGD	LIG_APCC_ABBAyCdc20_2	273:279	Mutation altering degron motif	0.6457

Kaplan plot for TMEM59 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM59

UniProt ID: Q9BXS4

Entrez ID: 9528

Protein name: Transmembrane protein 59 (Liver membrane-bound protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM59 in