DegronMD

Uniprot ID: Q9BXS4

Source protein: Transmembrane protein 59

Source gene: TMEM59

Class: LIG_APCC_ABBA_1

Location: 274:279

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8038

ASA_SCORE: 57.4833

COIL: 0.7518

CONS_SCORE: 0.7026

DSS_SCORE: 0.1123

HELIX: 0.146

FCONS_SCORE: 1.4201

RIG_SCORE: 0.8744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S271Y	TCGA-80-5608	LUAD	TCGA	LSIYGD	LIG_APCC_ABBA_1	0.25
p.S271Y	DO23693	LUAD	ICGC	LSIYGD	LIG_APCC_ABBA_1	0.25
p.A264S	TCGA-AP-A051	UCEC	TCGA	LSIYGD	LIG_APCC_ABBA_1	0.0556
p.A264S	DO42673	UCEC	ICGC	LSIYGD	LIG_APCC_ABBA_1	0.0556
p.M283I	TCGA-AX-A0J0	UCEC	TCGA	LSIYGD	LIG_APCC_ABBA_1	0.2222
p.M283I	DO41133	UCEC	ICGC	LSIYGD	LIG_APCC_ABBA_1	0.2222
p.M283I	SIDM00588	Oral Cavity Carcinoma	GDSC	LSIYGD	LIG_APCC_ABBA_1	0.2222
p.M283I	ACH-000546	Head and Neck Cancer	CCLE	LSIYGD	LIG_APCC_ABBA_1	0.2222
p.M283I	HSC-4	upper_aerodigestive_tract	COSMIC	LSIYGD	LIG_APCC_ABBA_1	0.2222
p.A264V	TCGA-B5-A1MX	UCEC	TCGA	LSIYGD	LIG_APCC_ABBA_1	0.0556
p.A264V	DO41999	UCEC	ICGC	LSIYGD	LIG_APCC_ABBA_1	0.0556
p.Y277C	DO222919	BTCA	ICGC	LSIYGD	LIG_APCC_ABBA_1	0.8198
p.A264D	DO229029	LICA	ICGC	LSIYGD	LIG_APCC_ABBA_1	0.0556
p.N289K	DO229036	LICA	ICGC	LSIYGD	LIG_APCC_ABBA_1	0.0556
p.L274Q	DO46546	OV	ICGC	LSIYGD	LIG_APCC_ABBA_1	0.7765
p.G278S	DO229208	THCA	ICGC	LSIYGD	LIG_APCC_ABBA_1	0.5882
p.G278R	SIDM00844	Burkitt's Lymphoma	GDSC	LSIYGD	LIG_APCC_ABBA_1	0.6457
p.G278R	ACH-000654	Lymphoma	CCLE	LSIYGD	LIG_APCC_ABBA_1	0.6457
p.G278R	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	LSIYGD	LIG_APCC_ABBA_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXS4	Transmembrane protein 59	LIG_APCC_ABBA_1	274:279	LSIYGD	APC,CDC20,FZR1	0.8038	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons